Blood pressure lowering in diabetes: a brief review of the current evidence and description of a new trial

Clinical and Experimental Pharmacology & Physiology
A PatelS MacMahon

Abstract

1. Diabetes is a major global public health problem. The prevalence of this disease is predicted to increase sharply in the coming decades, particularly in less-developed regions of the world. 2. Most premature morbidity and mortality associated with diabetes relates to markedly increased risks of major cardiovascular diseases, such as myocardial infarction and stroke (macrovascular events), as well as microvascular complications, such as nephropathy and retinopathy. 3. Hypertension is a prevalent and important risk factor for vascular events in these patients. However, observational data demonstrate a continuous relationship between blood pressure and risk of vascular events, suggesting that even those individuals considered normotensive may benefit from blood pressure lowering. 4. Trials of blood pressure lowering among mostly hypertensive individuals with diabetes have demonstrated benefit of intervention on macrovascular and microvascular outcomes. Recent data may suggest additional effects of angiotensin- converting enzyme inhibitors independent of blood pressure lowering. 5. Issues where data are lacking with respect to blood pressure lowering in diabetes include the effects of blood pressure lowering among non-hypertensi...Continue Reading

References

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Jan 20, 2000·The New England Journal of Medicine·UNKNOWN Heart Outcomes Prevention Evaluation Study InvestigatorsG Dagenais
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Citations

Aug 27, 2003·Metabolism: Clinical and Experimental·Diederick E Grobbee
Dec 14, 2011·Diabetes, Obesity & Metabolism·P Hamet
May 3, 2007·Blood Pressure·Vlado PerkovicUNKNOWN ADVANCE Collaborative Group
Feb 1, 2015·The Cochrane Database of Systematic Reviews·Diana V DoRobert N Frank

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