Blood pressure management in acute head injury.

Journal of Intensive Care Medicine
Monica Trivedi, Jonathan P Coles

Abstract

Head injury remains a major cause of preventable death and serious morbidity in young adults. Based on the available evidence, it appears that a cerebral perfusion pressure of 50 to 70 mm Hg is generally adequate to ensure cerebral oxygen delivery and prevent ischemia. However, evidence suggests that perfusion requirements may not only vary across the injured brain but also differ depending on the time since injury. Such heterogeneity, both within and between subjects, suggests that individualized therapy may be an appropriate treatment strategy. Future studies should aim to assess which groups of patients, and what regional pathophysiological derangements, may benefit with improvements in functional outcome from therapeutic increases or decreases in cerebral perfusion pressure beyond these proposed limits. Such functional improvements may be of immense importance to patients and require formal neurocognitive assessments to discriminate improvements.

References

Jan 1, 1978·Acta Anaesthesiologica Scandinavica·G E Cold, F T Jensen
Aug 1, 1976·The American Journal of Physiology·E T MacKenzieA M Harper
Jul 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·C S RobertsonR G Grossman
May 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·R BullockJ H Adams
Aug 1, 1990·The Journal of Trauma·M J Rosner, S Daughton
Feb 1, 1990·Journal of Neurosurgery·J L JaggiT W Langfitt
Feb 2, 1989·The American Journal of Cardiology·J M Simard, M Bellefleur
Sep 1, 1987·The Journal of Trauma·D G ChangarisC B Shields
Jan 1, 1985·British Journal of Anaesthesia·J D Miller
Feb 6, 1971·Lancet·D I Graham, J H Adams
Feb 1, 1984·Journal of Neurosurgery·M J Rosner, D P Becker
Dec 1, 1995·Journal of Neurosurgery·M J RosnerA H Johnson
Apr 1, 1994·Stroke; a Journal of Cerebral Circulation·D W NewellH R Winn
Jun 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·S P GopinathR G Grossman
Jan 1, 1994·Journal of Neurosurgical Anesthesiology·P A JonesN M Dearden
Feb 1, 1993·The Journal of Trauma·R M ChesnutM A Foulkes
Oct 1, 1996·Stroke; a Journal of Cerebral Circulation·M CzosnykaJ D Pickard
Oct 1, 1995·Acta Anaesthesiologica Scandinavica·B AsgeirssonH Sjöholm
Nov 1, 1996·Journal of Neurosurgery·M R McLaughlin, D W Marion
Apr 1, 1997·Journal of Neurosurgery·D F KellyD P Becker
Jun 1, 1997·Neurological Research·K L KieningW R Lanksch
Nov 21, 1998·Current Biology : CB·A M Owen
Apr 1, 1997·Bulletin of the American College of Surgeons·J E Wilberger
Nov 5, 1999·Critical Care Medicine·C S RobertsonR G Grossman
Sep 28, 2000·Trends in Neurosciences·J Duncan, A M Owen
Nov 4, 2000·Journal of Neurosurgery·B H VerweijC P Lee

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Citations

Sep 29, 2011·Anaesthesia·R T Protheroe, C L Gwinnutt

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