Blood pressure medication should be routinely dosed at bedtime. An internist's critical appraisal of the editorial by Rainhold Kreutz et al. (2020). Blood pressure medication should not be routinely dosed at bedtime. We must disregard the data from the HYGIA project. Blood Pressure. 29 (3):135-136.

Chronobiology International
António Pedro Machado

Abstract

The history of hypertension the past hundred years is a successful story of the fall of myths, beliefs, and assumptions under the weight of evidence. The recent editorial by Kreutz et al. (2020),"Blood pressure medication should not be routinely dosed at bedtime. We must disregard the data from the HYGIA project", published in Blood Pressure, conveys unjustified concerns founded on baseless doubts and suspicions about the Hygia Chronotherapy Trial. The physicians of Portugal are beginning to incorporate into routine clinical practice the proven methods of the Hygia Chronotherapy Trial - 48-hour ambulatory blood pressure monitoring and bedtime hypertension chronotherapy - to improve in a cost-effective matter the diagnosis and management of hypertension and to reduce the overwhelming burden of cardiovascular morbidity and mortality in our country.

References

Jan 20, 2000·The New England Journal of Medicine·UNKNOWN Heart Outcomes Prevention Evaluation Study InvestigatorsG Dagenais
Jul 27, 2000·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Y SuzukiT Ozawa
Sep 22, 2010·Chronobiology International·Ramón C HermidaJosé R Fernández
Apr 25, 2013·European Journal of Internal Medicine·Alfredo De GiorgiRoberto Manfredini
Dec 18, 2014·The Annals of Pharmacotherapy·Paul M StrangesAmie D Brooks
Sep 25, 2015·Diabetologia·Ramón C HermidaJosé R Fernández
Jun 24, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Sante D PierdomenicoEttore Porreca
Sep 30, 2018·Current Hypertension Reports·N P BowlesS A Shea

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