Blood pressure normalization via pharmacotherapy improves cutaneous microvascular function through NO-dependent and NO-independent mechanisms

Microcirculation : the Official Journal of the Microcirculatory Society, Inc
Daniel H CraigheadLacy M Alexander

Abstract

Hypertension is associated with endothelial dysfunction and vascular remodeling. To assess effects of antihypertensive pharmacotherapy on eNOS- and iNOS-dependent mechanisms and maximal vasodilator capacity in the cutaneous microvasculature. Intradermal microdialysis fibers were placed in 15 normotensive (SBP 111±2 mm Hg), 12 unmedicated hypertensive (SBP 142±2 mm Hg), and 12 medicated hypertensive (SBP 120±2 mm Hg) subjects. Treatments were control, iNOS-inhibited (1400w), and NOS-inhibited (l-NAME). Red cell flux, measured during local heating (42°C) and ACh dose-response protocols, was normalized to CVC (flux MAP-1 ) and a percentage of maximal vasodilation (%CVCmax ). Compared to normotensives, ACh-mediated vasodilation was attenuated in the hypertensive (P<.001), but not in medicated subjects (P=.83). NOS inhibition attenuated ACh-mediated vasodilation in normotensives compared to hypertensive (P<.001) and medicated (P<.001) subjects. With iNOS inhibition, there was no difference in ACh-mediated vasodilation between groups. Compared to the normotensives, local heat-induced vasodilation was attenuated in the hypertensives (P<.001), but iNOS inhibition augmented vasodilation in the hypertensives so this attenuation was aboli...Continue Reading

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Citations

Aug 1, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Gabrielle A DillonLacy M Alexander
Jun 20, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Brett J WongArshed A Quyyumi
Nov 24, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Daniel H CraigheadLacy M Alexander
Sep 2, 2017·Journal of Applied Physiology·Caroline J SmithLacy M Alexander
Jul 22, 2017·Journal of Applied Physiology·W Larry Kenney
Sep 4, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Gabrielle A DillonLacy M Alexander

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