Blood pressure profile and treatment quality in liver allograft recipients-benefit of tacrolimus versus cyclosporine

Transplantation Proceedings
R DikowM Zeier

Abstract

Organ transplant recipients display a high cardiovascular mortality rate. The type of immunosuppression has a major impact on cardiovascular risk factors (e.g., hypertension [HTN]). We assessed 24-hour blood pressure (BP) and metabolic profiles in a cohort of 106 long-term liver allograft recipients treated with either tacrolimus (Tac) or cyclosporine (CyA). The median age of patients was 50.8 years (range, 11 to 77) and the median time of follow-up was 65.4 months (ranges 12 to 168). Immunosuppression included low-dose steroids and either Tac (n = 46) or CyA (n = 60). Twenty-four-hour BP measurements revealed a significant difference in systolic BP (127.1 mmHg [94 to 163] Tac versus 132.7 mmHg [103 to 177] CyA; P <.03), and in mean arterial and diastolic blood pressures. In addition, the relative number of normotensive patients was significantly higher among Tac-treated patients (69.6% versus 34.8%). It is of note that the true incidence of HTN was higher after the number of patients with a pathological 24-h BP measurement was added to the initial number of patients already known to have HTN. No less than 76.4% of all long-term liver transplanted patients showed HTN. The results were unrelated to cumulative steroid dosage, fre...Continue Reading

References

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Citations

Oct 15, 2011·Transplantation Proceedings·E HryniewieckaL Paczek
Sep 7, 2011·Gastroenterology Clinics of North America·David H OusteckyKenneth D Rothstein
Jul 4, 2007·Clinics in Liver Disease·Lawrence U Liu, Thomas D Schiano
Jun 27, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Alessandra GaliotoPaolo Angeli
Apr 7, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K BoudjemaE Bellissant
Oct 21, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Santiago J Muñoz, Hisham Elgenaidi
May 9, 2006·Pediatric Transplantation·Tomás SeemanJan Janda
Feb 9, 2018·Clinical and Experimental Hypertension : CHE·Ewa HryniewieckaLeszek Paczek

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