Blood Pressure Reactivity to Psychological Stress in Young Adults and Cognition in Midlife: The Coronary Artery Risk Development in Young Adults (CARDIA) Study

Journal of the American Heart Association
Yuichiro YanoKiang Liu

Abstract

The classic view of blood pressure (BP) reactivity to psychological stress in relation to cardiovascular risks assumes that excess reactivity is worse and lower reactivity is better. Evidence addressing how stress-induced BP reactivity in young adults is associated with midlife cognitive function is sparse. We assessed BP reactivity during a star tracing task and a video game in adults aged 20 to 32 years. Twenty-three years later, cognitive function was assessed with use of the Digit Symbol Substitution Test (a psychomotor speed test), the Rey Auditory Verbal Learning Test (a verbal memory test), and the modified Stroop test (an executive function test). At the time of follow-up, participants (n=3021) had a mean age of 50.2 years; 56% were women, and 44% were black. In linear regression models adjusted for demographic and clinical characteristics including baseline and follow-up resting BP, lower systolic BP (SBP) reactivity during the star tracing and video game was associated with worse Digit Symbol Substitution Test scores (β [SE]: 0.11 [0.02] and 0.05 [0.02], respectively) and worse performance on the Stroop test (β [SE]: -0.06 [0.02] and -0.05 [0.02]; all P<0.01). SBP reactivity was more consistently associated than diast...Continue Reading

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Citations

Mar 21, 2017·Journal of the American Heart Association·J Richard JenningsPeter J Gianaros
Sep 9, 2017·Stroke; a Journal of Cerebral Circulation·Philip B GorelickUNKNOWN American Heart Association/American Stroke Association
Dec 8, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Simin MahinradFarzaneh A Sorond
Feb 21, 2019·Journal of Psychosomatic Research·Neha A John-HendersonAnnie T Ginty

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