PMID: 9180665Jun 1, 1997Paper

Blood pressure reduction and tolerability of felodipine ER in older and younger hypertensive patients. The Felodipine ER in the Elderly versus Young Working Group

Journal of the American Geriatrics Society
T C Fagan

Abstract

To evaluate and compare blood pressure reduction and tolerability of felodipine ER (extended-release), in younger and older patients. A multicenter, double-blind, placebo-controlled, parallel group study. Nineteen study sites; approximately half of the sites were at academic medical centers and half were in private primary care practices. Patients were non-hospitalized and free-living. There were 243 younger (< or = 61 years) and older (> or = 64 years) patients, age range 26 to 83, with sitting diastolic blood pressure (SDBP) of 95-115 mm Hg (higher stage 1 to lower stage 3) on placebo. Patients volunteered for the study. After a 2 to 4 week, single-blind, placebo baseline period, patients with SDBP of 95-115 mm Hg were randomized to treatment with felodipine ER 2.5 mg qd or placebo at a ratio of 3:1, felodipine:placebo. The dose of felodipine ER was increased to 5 mg qd after 3 weeks and to 10 mg qd after 6 weeks if the SDBP was greater than 90 mm Hg. The main outcome measure was change in SDBP. Secondary Outcome measures were change in sitting systolic blood pressure (SSBP) and percent of responders, defined as SDBP less than 90 mm Hg or a > or = 10 mm Hg reduction. Other measurements included heart rate, weight, routine lab...Continue Reading

References

Dec 1, 1991·Clinical Pharmacokinetics·P H Dunselman, B Edgar
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Nov 1, 1995·Journal of the American Geriatrics Society·M PahorR J Havlik
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Mar 1, 1994·Clinical Cardiology·C R Conti

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