Blood pressure-related hypoalgesia: a systematic review and meta-analysis.

Journal of Hypertension
Elena MakovacCristina Ottaviani

Abstract

Spontaneous or experimentally induced high blood pressure (BP) is associated with reduced pain perception, known as BP-related hypoalgesia. Despite its clinical implications, such as the interference with early detection of myocardial infarction in 'at risk' groups, the size of the association between high BP and pain has not yet been quantified. Moreover, the distinct association between high BP and physiological or psychological components of pain has not yet been considered so far. The aim of this study was to overcome this gap by performing separate meta-analyses on nociceptive response versus quantifiable perceptual measures of pain in relation to high BP. PubMed and Web of Knowledge databases were searched for English language studies conducted in humans. Fifty-nine studies were eligible for the analyses. Pooled effect sizes (Hedges' g) were compared. Random effect models were used. Results show that higher BP is significantly associated with lower nociceptive response (g = 0.38; k = 6) and reduced pain perception, assessed by quantifiable measures (g = 0.48; k = 59). The association between BP and pain perception, derived from highly heterogeneous studies, was characterized by significant publication bias. BP assessment,...Continue Reading

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Citations

Jan 9, 2021·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Julian F ThayerDeWayne P Williams
May 30, 2021·Psychological Research·Alessandro MontiSalvatore Maria Aglioti

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