PMID: 2490825May 1, 1989Paper

Blood pressure (systolic and diastolic) and risk of fatal coronary heart disease

Hypertension
J StamlerD N Wentworth

Abstract

Among the 356,222 men screened for the Multiple Risk Factor Intervention Trial who had no history of hospitalization for heart attack at entry, more than 2,000 coronary deaths occurred during 6 years of follow-up. With this large data set, detailed cross-tabulations clearly and simply showed the strong graded relation between blood pressure and coronary heart disease death. This risk gradient was evident in each of five age groups ranging from 35 to 57 years and for levels of diastolic blood pressure ranging from less than 75 mm Hg to greater than 115 mm Hg. Systolic blood pressure was more strongly associated with coronary heart disease death than was diastolic blood pressure, and isolated systolic blood pressure elevation was found to be an important risk factor in these middle-aged men. The risk of coronary death was increased among hypertensive men who had elevated serum cholesterol levels or who smoked cigarettes. Because less than 10% of hypertensive men had cholesterol levels in the lowest quintile (below 182 mg/dl) and were nonsmokers, a multi-intervention approach for the large majority of hypertensive persons is clearly indicated. Risks of death were also substantially increased among those hypertensive men who alread...Continue Reading

References

Apr 1, 1971·The American Journal of Cardiology·W B KannelM J Schwartz

❮ Previous
Next ❯

Citations

Dec 1, 1991·Cardiovascular Drugs and Therapy·J D Swales
Oct 7, 2004·Aging Clinical and Experimental Research·Morad AskariLewis A Lipsitz
Dec 25, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Azhar SupariwalaAlan Rozanski
Jan 1, 1995·Archives of Gerontology and Geriatrics·R AntonicelliE Paciaroni
Mar 1, 2006·International Journal of Cardiology·José R LanzJosé E Krieger
Sep 30, 1996·The American Journal of Medicine·D S HanesJ R Sowers
Dec 20, 1996·Atherosclerosis·P Roma, A L Catapano
Jul 18, 2000·Journal of the American College of Cardiology·V VaccarinoH M Krumholz
Mar 16, 2000·Clinical Endocrinology·N C NathwaniP C Hindmarsh
May 1, 1995·Journal of Internal Medicine·L Werkö
May 11, 1991·BMJ : British Medical Journal·A G ShaperP W Macfarlane
Sep 24, 2008·Circulation·Tanika N KellyJiang He
Oct 31, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Dimitris P PapadopoulosVasilios Papademetriou
Oct 18, 2012·Oman Medical Journal·Samir Burhanaldin Al-MukhtarBassam Edward Hanna
Jul 30, 2014·Nature Reviews. Cardiology·Jan A Staessen
Jan 31, 2003·The Journal of Clinical Hypertension·Claudio BorghiAntonio Gaddi
Apr 17, 2001·American Journal of Therapeutics·J C Somberg
Mar 20, 2009·Journal of Tropical Pediatrics·Neamatollah AtaeiMohammad Iranmanesh
Jun 24, 2006·Journal of Cardiovascular Pharmacology·Marjorie L McCulloughNorman K Hollenberg
Apr 12, 2012·QJM : Monthly Journal of the Association of Physicians·C J FerroJ N Townend
Nov 1, 1993·Clinical and Experimental Hypertension : CHE·P Sleight
Apr 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J M FlackP Esunge
Apr 5, 2003·Kidney International·Jacques BlacherGérard M London
Dec 26, 2008·Journal of Clinical Epidemiology·Katy J L BellLes Irwig
Jun 16, 2009·European Journal of Internal Medicine·Raymond FarahMakhoul Nicola
Jun 28, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Giulia Dell'OmoRoberto Pedrinelli
Jul 19, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·M BurgmaierN Marx
Jul 18, 1991·The American Journal of Medicine·J M Flack, J R Sowers

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.