PMID: 18418521Apr 18, 2008Paper

Blood pressure variability and arterial elasticity in hyperlipidaemic subjects

Singapore Medical Journal
H M RafidahM N Noriah

Abstract

It is debatable whether the assessment of low density lipoprotein or total cholesterol (TC) alone is sufficient to identify an individual's risk of having myocardial infarction. In the Framingham study, the risk of coronary artery disease was better indicated by an increase in the TC to high density lipoprotein cholesterol (TC: HDL) ratio. The aim of this study is to determine the relationship between blood pressure variability (BPV) and arterial compliances in hyperlipidaemics, which was defined as TC:HDL of more than 5.0 as compared to normolipidaemics. 22 subjects with hyperlipidaemia were age-, gender- and weight-matched with normolipidaemic controls. 24-hour ambulatory blood pressure monitoring was recorded and arterial compliances were measured. There were significantly higher 24-hour systolic (SBP) (19.9 +/- 6.1 mmHg vs. 16.1 +/- 4.4 mmHg, p-value is less than 0.01), diastolic (16.6 +/- 4.7 mmHg vs. 13.9 +/- 4.8 mmHg, p-value is less than 0.05) and mean arterial (16.3 +/- 4.9 mmHg vs. 13.3 +/- 4.7 mmHg, p-value is less than 0.05) BPVs in the hyperlipidaemic group as compared to the normolipidaemic group. There were no significant differences in large and small arterial compliances between groups. There was a significant ...Continue Reading

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