Blood pressure variability and brain morphology in elderly women without cardiovascular disease

Neurology
Bernhard HaringSylvia Wassertheil-Smoller

Abstract

To examine the relationship between blood pressure (BP) variability (BPV), brain volumes, and cognitive functioning in postmenopausal women with few modifiable cardiovascular risk factors. Study participants consisted of postmenopausal women enrolled in the Women's Health Initiative Memory MRI study (WHIMS-MRI) without cardiovascular disease, diabetes mellitus, hypertension, or current smoking at baseline (1996-1999). BP readings were taken at baseline and each annual follow-up visit. BPV was defined as the SD associated with a participant's mean BP across visits and the SD associated with the participant's regression line with BP regressed across visits. Brain MRI scans were performed between 2004 and 2006. Cognitive functioning was assessed at baseline and annually thereafter with the Modified Mini-Mental State Examination (3MSE) scoring until 2008. The final sample consisted of 558 women (mean age 69 years, median follow-up time [interquartile range] 8 [0.8] years). In adjusted models including mean systolic BP, women in the highest tertile of systolic BPV had lower hippocampal volumes and higher lesion volumes compared to women in the lowest tertile. No relationship between BPV and 3MSE scoring was detected. In postmenopaus...Continue Reading

References

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Citations

Jul 28, 2020·American Journal of Hypertension·Yuan MaChristophe Tzourio
Feb 11, 2020·Journal of Alzheimer's Disease : JAD·Rianne A A de HeusJurgen A H R Claassen
Apr 3, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M NagaiM Kato
Jun 26, 2021·Stroke; a Journal of Cerebral Circulation·Chenglong LiWuxiang Xie

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