Blood pressure variability and microvascular dysfunction: the Maastricht Study.

Journal of Hypertension
Tan Lai ZhouCoen D A Stehouwer

Abstract

Microvascular dysfunction (MVD) contributes to stroke, dementia, depression, retinopathy and chronic kidney disease. However, the determinants of MVD are incompletely understood. Greater blood pressure variability (BPV) may be one such determinant. We used cross-sectional data of The Maastricht Study (n = 2773, age 59.9 years; 51.9% men) to investigate whether greater very short- to mid-term BPV is associated with various MVD measures. We standardized and averaged within-visit, 24-h and 7-day BPV into a systolic and a diastolic BPV composite score. MVD measures included a composite score of MRI cerebral small vessel disease (CSVD) features (total brain parenchymal volume, white matter hyperintensity volume, lacunar infarcts and cerebral microbleeds), a composite score of flicker light-induced retinal arteriolar and venular dilation response, albuminuria, heat-induced skin hyperemia and a composite score of plasma biomarkers of MVD (sICAM-1, sVCAM-1, sE-selectin and von Willebrand Factor). We used linear regression adjusted for age, sex, glucose metabolism status, mean 24-h systolic or DBP, cardiovascular risk factors and antihypertensive medication. We found that higher systolic and diastolic BPV composite scores (per SD) were ...Continue Reading

References

Jan 1, 1990·Epidemiology·K J Rothman
Jan 1, 2000·The Medical Journal of Australia·J Chalmers
Apr 12, 2005·BMJ : British Medical Journal·Antonia TrichopoulouDimitrios Trichopoulos
Jun 16, 2005·Neurology·Iris B GoldsteinDavid Shapiro
Jan 14, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Alfonso TatascioreRaffaele DE Caterina
Apr 7, 2009·NeuroImage·Renske de BoerWiro J Niessen
Aug 28, 2010·Diabetes Care·Eric S KilpatrickStephen L Atkin
Jul 21, 2011·Microvascular Research·Gerhard GarhöferLeopold Schmetterer
Aug 5, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Emi UshigomeNaoto Nakamura
Oct 21, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tatsuo KawaiHiromi Rakugi
Jan 27, 2012·Journal of Hypertension·Luc M Van BortelUNKNOWN European Network for Noninvasive Investigation of Large Arteries
Jul 6, 2012·The New England Journal of Medicine·Lesley A InkerUNKNOWN CKD-EPI Investigators
Nov 8, 2012·Current Opinion in Nephrology and Hypertension·Anil K BidaniKaren A Griffin
Jan 10, 2013·Reviews in Endocrine & Metabolic Disorders·Dennis M J MurisCoen D A Stehouwer
Apr 23, 2013·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Tavis S CampbellBlaine Ditto
Jul 23, 2013·Lancet Neurology·Joanna M WardlawUNKNOWN STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1)
Sep 27, 2013·Current Vascular Pharmacology·Marilyn BurkeRichard J Roman
Nov 29, 2013·Journal of Human Hypertension·N PagonasT H Westhoff
May 3, 2014·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·L Schwingshackl, G Hoffmann
Dec 20, 2014·American Journal of Hypertension·Thomas T van SlotenCoen D Stehouwer
Mar 5, 2015·Nordic Journal of Psychiatry·Agneta PetterssonLisa Ekselius
Mar 21, 2015·Current Hypertension Reports·Gianfranco ParatiGrzegorz Bilo
Apr 2, 2015·Neuroscience and Biobehavioral Reviews·Thomas T van SlotenCoen D A Stehouwer
Apr 22, 2015·Current Medicinal Chemistry·Panagiota PietriDimitris Tousoulis
Mar 13, 2016·Brain, Behavior, and Immunity·Fleur E P van DoorenFrans Pouwer
May 11, 2016·Journal of the American Society of Nephrology : JASN·Remy J H MartensCoen D A Stehouwer
Dec 17, 2016·Lancet·Londa SchiebingerVirginia M Miller
Apr 13, 2017·American Journal of Hypertension·Anna MaseliDavid Conen

❮ Previous
Next ❯

Citations

Aug 23, 2020·International Journal of Molecular Sciences·Michele ProvenzanoMichele Andreucci
Jun 3, 2021·Journal of Hypertension·Tan Lai Zhou, Daan J L van Twist

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

Journal of the American Heart Association
Enayet K ChowdhurySecond Australian National Blood Pressure Study Group <xref ref-type="author-note" rid="jah34572-note-1001"><sup>†</sup></x
© 2022 Meta ULC. All rights reserved