Blood Pressure Variability and the Risk of Dementia: A Nationwide Cohort Study.

Hypertension
Jung Eun YooSangYun Kim

Abstract

To investigate the association between visit-to-visit variability in blood pressure and the incidence of dementia and its subtypes in a general population, we conducted a population-based retrospective cohort study using the Korean National Health Insurance System database. We identified 7 844 814 subjects without a history of any dementia who underwent ≥3 health examinations from 2005 to 2012 in the Korean National Health Insurance System cohort. Blood pressure variability (BPV) was measured using the variability independent of the mean, coefficient of variation, and SD. During the median follow-up of 6.2 years, there were 200 574 cases of all-cause dementia (2.8%), 165 112 cases of Alzheimer's disease (2.1%), and 27 443 cases of vascular dementia (0.3%). There was a linear association between higher BPV and outcome measures. In the multivariable adjusted model, the hazard ratios and 95% CIs of all-cause dementia were 1.06 (1.04-1.07) for the highest quartile of variability independent of the mean of diastolic blood pressure only, 1.09 (1.08-1.11) for that of systolic blood pressure only, and 1.18 (1.16-1.19) for that of both systolic and diastolic blood pressure compared with subjects having no highest quartile for BPV. Consi...Continue Reading

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Citations

Sep 10, 2020·Hypertension·Pedro Guimarães CunhaAlexandre Persu
Oct 29, 2020·Frontiers in Aging Neuroscience·Knut HestadBjørn Heine Strand
May 26, 2021·Neurobiology of Aging·Isabel J SibleUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jun 20, 2021·American Journal of Preventive Medicine·Rui ZhouXian-Bo Wu
Jun 26, 2021·Stroke; a Journal of Cerebral Circulation·Chenglong LiWuxiang Xie
Jun 29, 2021·Journal of the American Heart Association·Michael E ErnstAnne M Murray
Aug 11, 2021·Journal of Affective Disorders·Ji Hyun BaekHong Jin Jeon
Aug 17, 2021·Kardiologiia·O D OstroumovaA A Kirichenko
Sep 29, 2021·Brain Imaging and Behavior·Isabel J SibleUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Sep 15, 2021·American Journal of Hypertension·Michael E ErnstUNKNOWN ASPirin in Reducing Events in the Elderly Investigator Group

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