Blood pressure variability in Alzheimer's disease and frontotemporal dementia: the effect on the rate of cognitive decline

Journal of Alzheimer's Disease : JAD
Simona LattanziMauro Silvestrini

Abstract

The link between vascular disease and cognitive impairment is a matter of an ongoing debate, and different cardiovascular conditions have been found to be predictors of the clinical development and progression of cognitive dysfunction. To compare the influence of visit-to visit blood pressure (BP) variability on the rate of cognitive decline in Alzheimer's disease (AD) and frontotemporal dementia (FTD). The patients affected by AD and FTD consecutively admitted to our center from January 2007 to September 2012 were evaluated every three months for a one-year period. The BP mean and coefficient of variation as index of variability were obtained for both systolic and diastolic values. Progression of cognitive decline was investigated using the Mini-Mental State Examination administered at entry and at the end of the follow-up. Two-hundred and forty-eight AD and eighty-one FTD patients were enrolled. Systolic and diastolic BP mean and variability were comparable between the two groups. Systolic BP variability (BPV) was associated with the rate of cognitive impairment in AD (B = 0.367, beta = 0.739, R2 = 0.594, adjusted R(2) = 0.567; p < 0.001), but not in FTD patients; no relationship emerged between any other BP index and cogniti...Continue Reading

Citations

May 31, 2018·The Journal of Clinical Hypertension·Simona LattanziMauro Silvestrini
Sep 28, 2018·The Journal of Clinical Hypertension·Simona LattanziMauro Silvestrini
Oct 31, 2018·The Journal of Clinical Hypertension·Simona LattanziMauro Silvestrini
Mar 24, 2018·Nature Reviews. Neurology·Rebekah M AhmedMatthew C Kiernan
Dec 17, 2015·Geriatrics & Gerontology International·Michiaki NagaiKazuomi Kario
Sep 10, 2019·The Journal of Clinical Hypertension·Simona LattanziMauro Silvestrini
Sep 24, 2019·Hypertension·Rianne A A de HeusUNKNOWN NILVAD Study Group
Jul 5, 2017·Neurology·Simona Lattanzi, Mauro Silvestrini
Jul 18, 2018·Neurology·Simona Lattanzi, Mauro Silvestrini
May 10, 2020·Alzheimer Disease and Associated Disorders·Juri KitamuraKazuomi Kario
Jul 28, 2020·American Journal of Hypertension·Yuan MaChristophe Tzourio
Feb 22, 2018·The Journal of Clinical Hypertension·Simona LattanziMauro Silvestrini
Apr 26, 2018·The Journal of Clinical Hypertension·Simona LattanziMauro Silvestrini
Feb 12, 2019·Journal of Alzheimer's Disease : JAD·Corinne E FischerUNKNOWN and the PACT-MD Study Group
Jun 10, 2017·Journal of Alzheimer's Disease : JAD·Michiaki NagaiAkane Tsuchiya
Mar 24, 2018·The Journal of Clinical Hypertension·Simona LattanziMauro Silvestrini
Feb 22, 2018·Oncotarget·Lu YangYuesheng Zhang
Jul 26, 2019·Acta Neurologica Scandinavica·Dibashree TamuliKishore K Deepak
Nov 14, 2018·Journal of Human Hypertension·Naoyuki TakashimaUNKNOWN INTERMAP Study Group
Oct 29, 2020·Frontiers in Aging Neuroscience·Knut HestadBjørn Heine Strand
Sep 29, 2021·Brain Imaging and Behavior·Isabel J SibleUNKNOWN Alzheimer’s Disease Neuroimaging Initiative

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