Blood pressure variability increases with advancing chronic kidney disease stage: a cross-sectional analysis of 16 546 hypertensive patients

Journal of Hypertension
Pantelis SarafidisJosé R Banegas

Abstract

Increased BP-variability predicts cardiovascular morbidity and mortality in hypertensives. This study aimed to examine short-term BP-variability according to renal function stage. We included 16 546 patients [10 270 (62.1%) without/6276 (38.9%) with CKD Stage 1-5] from the Spanish Ambulatory-Blood-Pressure Monitoring (ABPM) Registry. Stages of CKD were defined according to K/DIGO criteria, based on estimated glomerular filtration rate calculated with the CKD-EPI equation and albumin-to-creatine ratio. BP-variability was assessed with standard deviation (SD), weighted SD (wSD), coefficient of variation (CV), and average real variability (ARV). Compared with those without CKD, a lower proportion of CKD patients were dippers (51.9 versus 39.6%; P < 0.001). Across CKD stages, a progressive decrease in dipper (from 39.1 to 20.4%; P < 0.001) and increase in riser proportion (from 12.3 to 36.7%; P < 0.001) were noted. Patients with CKD had significantly higher SBP SD, wSD, CV and ARV and lower DBP SD compared with those without CKD (P < 0.001). Within CKD Stages, an increasing trend from Stage 1 towards Stage 5 was observed for SBP SD (from 13.8 ± 3.7 to 15.6 ± 5.4 mmHg), wSD (from 12.0 ± 3.2 to 13.9 ± 5.1 mmHg), CV (from 10.4 ± 2.7 t...Continue Reading

References

Apr 15, 1978·Lancet·M W Millar-CraigE B Raftery
Dec 12, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C K FarmerP Sharpstone
Apr 26, 2003·Journal of Hypertension·Eoin O'BrienUNKNOWN European Society of Hypertension Working Group on Blood Pressure Monitoring
Apr 17, 2004·Kidney International·Jutta NeumannPeter J Blankestijn
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Nov 1, 2006·Hypertension·José R BanegasUNKNOWN Spanish Society of Hypertension Ambulatory Blood Pressure Monitoring Registry Investigators
Apr 7, 2007·Journal of Hypertension·Manuel GorostidiUNKNOWN Spanish Society of Hypertension ABPM Registry investigators
Apr 1, 2008·The American Journal of Medicine·Pantelis A SarafidisGeorge L Bakris
Dec 3, 2008·Hypertension·Velvie PogueUNKNOWN African American Study of Kidney Disease and Hypertension Collaborative Research Group
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Jul 8, 2009·Hypertension·Rajiv AgarwalLindsey A Hummel
Aug 1, 2009·Journal of Hypertension·Efstathios ManiosNikolaos Zakopoulos
Dec 5, 2009·The American Journal of Medicine·José R BanegasLuis M Ruilope
Mar 10, 2010·Hypertension·Tine W HansenUNKNOWN International Database on Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes Investigators
Jun 29, 2011·Archives of Internal Medicine·Roberto MinutoloLuca De Nicola
Aug 13, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Manuel GorostidiUNKNOWN Spanish Society of Hypertension ABPM Registry investigators
Feb 22, 2012·American Journal of Nephrology·Pantelis A SarafidisIain C Macdougall
Nov 28, 2012·Chronobiology International·Artemio MojónUNKNOWN Hygia Project Investigators
Feb 13, 2013·Nature Reviews. Cardiology·Gianfranco ParatiGrzegorz Bilo
May 22, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Manuel GorostidiUNKNOWN Spanish ABPM Registry Investigators
Jun 3, 2014·Journal of Hypertension·Gianfranco ParatiYuqing Zhang
Jan 1, 2013·Kidney International Supplements
Jan 31, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Antonios KarpetasAnastasios N Lasaridis
Feb 24, 2015·Advances in Chronic Kidney Disease·Arjun D Sinha, Rajiv Agarwal
Mar 21, 2015·Current Hypertension Reports·Gianfranco ParatiGrzegorz Bilo
Nov 7, 2015·European Journal of Clinical Investigation·Manuel GorostidiLuis M Ruilope
Mar 2, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Rajiv SaranRichard A Hirth

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Citations

Mar 27, 2018·Journal of Hypertension·Grzegorz Bilo, Gianfranco Parati
Jul 14, 2018·The Journal of Clinical Hypertension·Gianfranco ParatiGrzegorz Bilo
Sep 6, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pantelis A SarafidisGianfranco Parati
Jan 20, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Daniel Murphy, Paul E Drawz
Jan 4, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Francesca MallamaciCarmine Zoccali
Jun 5, 2019·American Journal of Hypertension·Charalampos LoutradisAikaterini Papagianni
Jun 10, 2020·Journal of Hypertension·Tan Lai ZhouCoen D A Stehouwer
Sep 19, 2019·The Journal of Clinical Hypertension·Kazuomi KarioJi-Guang Wang
Jan 1, 2020·Clinical Journal of the American Society of Nephrology : CJASN·Sehoon ParkHajeong Lee
Apr 25, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Maria Eleni AlexandrouPantelis Sarafidis
Jun 9, 2020·Journal of the American Heart Association·Qin WangUNKNOWN C‐STRIDE (Chinese Cohort Study of Chronic Kidney Disease)* †
Jun 15, 2018·Journal of Human Hypertension·Fabio AngeliGianpaolo Reboldi
Jul 18, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Konstantinos ManousopoulosEfstathios Manios
Jul 21, 2020·Journal of Hypertension·Xianhui Qin, Xiping Xu
Oct 4, 2020·Nutrients·Juan Serna, Clemens Bergwitz
Jan 15, 2021·Vascular Health and Risk Management·Erietta PolychronopoulouMichel Burnier
Mar 12, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Roberto MinutoloLuca De Nicola
Jun 11, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Christian OttRoland E Schmieder
Sep 15, 2021·American Journal of Hypertension·Michael E ErnstUNKNOWN ASPirin in Reducing Events in the Elderly Investigator Group
Jul 23, 2021·Blood Purification·Venkata R Latha GullapudiNicholas M Selby

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