PMID: 8964946Mar 7, 1996Paper

Blood-pressure variability is buffered by nitric oxide

Journal of the Autonomic Nervous System
B NafzP B Persson

Abstract

The baroreflex constitutes the only hitherto known buffer of rapid blood pressure oscillations. In order to investigate the influence of nitric oxide (NO) and the sinoaortic and cardiopulmonary baroreflex pathways on the dynamic properties of blood pressure control, we determined the power spectra of 24-h blood pressure time series of conscious dogs. This was done in the intact state (n = 6), during blockade of NO synthesis via the false substrate NG-nitro-L-arginine ((L-NNA), 16.5 +/- 2 mg/kg body weight i.v., n = 5) and in animals devoid of baroreceptor reflexes (n = 5). After L-NNA, blood pressure (BP) increased by roughly 20 mmHg to 137 +/- 6 mmHg (P < 0.01), heart rate decreased from 97 +/- 6 to 68 +/- 3 beats/min (P < 0.01). The power of blood pressure variations within the frequency range 0.1-0.5 Hz was tripled by L-NNA (P < 0.05). By comparison total sinoaortic and cardiopulmonary denervation increased power of slower oscillations ( < 0.1 Hz) by a factor of 4.7 (P < 0.05). Thus, NO and the baroreceptor reflex both play an important role as physiological blood pressure buffers, NO for rapid (0.1-0.5 Hz) and the baroreflex for slower fluctuations ( < 0.1 Hz).

Citations

Feb 28, 2007·Clinical and Experimental Pharmacology & Physiology·Harald M Stauss
Jul 8, 2008·Autonomic Neuroscience : Basic & Clinical·Geisa C S V TeziniHugo C D Souza
Apr 30, 2014·Frontiers in Physiology·Caroline A Rickards, Yu-Chieh Tzeng
Mar 18, 2005·Theoretical Biology & Medical Modelling·Bernhard M Schmitt
Jun 6, 2014·Acta Physiologica Hungarica·Ines DrenjancevicK Selthofer-Relatic
Sep 14, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Paola A Lanfranchi, Virend K Somers
Jan 5, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·D S Latchman
Dec 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Simon C Malpas
Sep 18, 2002·Journal of Applied Physiology·William H CookeBenjamin D Levine
Aug 2, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Paola A LanfranchiPantaleo Giannuzzi
Jan 25, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·B J JanssenJ F Smits
Jan 6, 2021·Journal of Hypertension·Nour-Mounira Z BakkarSouha A Fares

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