PMID: 8593529Sep 1, 1995Paper

Blood product costing: relationship to price and clinical efficacy

Transfusion Medicine
P M Trenchard, R Dixon

Abstract

Detailed information is provided about primary product costing and price issues as they affect transfusion manufacturing practice and clinical transfusion practice. Product price is shown to have a crucial influence upon clinical practice and associated research. By focusing particularly upon cost-benefit analysis of blood product transfusion therapy a substantive conclusion is drawn that price should equal the associated manufacturing cost. Clinical outcome studies relate clinical efficacy to the manufacturing specification of the product, which should therefore determine the product cost. Thus, the true manufacturing cost is the sum of all the process activity costs that create the final product specification, e.g. red cell number+volume reduction+leucocyte reduction+microbiological safety, for processed red cells. Sometimes different product specifications may compete for a single activity cost, e.g. one-spin processing achieves volume reduction and leucocyte reduction for processed red cells but also plasma removal for protein fractionation. A method for understanding the relative clinical importance of different products is described, which guides the cost allocation process. Furthermore, for some products there is uncerta...Continue Reading

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Citations

Feb 6, 1998·Transfusion Science·S W Renner
Jan 6, 2000·Transfusion Science·M ValbonesiG Lercari
Sep 15, 2005·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Brian CusterMichael P Busch
Nov 1, 1995·Nature Medicine·R M Winslow
Mar 6, 2009·Analytical and Bioanalytical Chemistry·Maria G E G BremerWillem Haasnoot

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