Blood profile holds clues to role of infection in a premonitory state for idiopathic parkinsonism and of gastrointestinal infection in established disease.

Gut Pathogens
André CharlettIngvar T Bjarnason

Abstract

The two-stage neuroinflammatory process, containment and progression, proposed to underlie neurodegeneration may predicate on systemic inflammation arising from the gastrointestinal tract. Helicobacter infection has been described as one switch in the pathogenic-circuitry of idiopathic parkinsonism (IP): eradication modifies disease progression and marked deterioration accompanies eradication-failure. Moreover, serum Helicobacter-antibody-profile predicts presence, severity and progression of IP. Slow gastrointestinal-transit precedes IP-diagnosis and becomes increasingly-apparent after, predisposing to small-intestinal bacterial-overgrowth (SIBO). Although IP is well-described as a systemic illness with a long prodrome, there has been no comprehensive overview of the blood profile. Here, it is examined in relation to Helicobacter status and lactulose-hydrogen-breath-testing for SIBO. A robust finding of reduced lymphocyte count in 126 IP-probands and 79 spouses (without clinically-definite IP), compared with that in 381 controls (p < 0.001 in each case), was not explained by Helicobacter-status or breath-hydrogen. This complements a previous report that spouses were 'down-the-pathway' to 'clinically-definite' disease. In 205 o...Continue Reading

References

Jan 1, 1979·Scandinavian Journal of Gastroenterology·J M RhodesD P Jewell
Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Dec 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·R J SwinglerC P Warlow
Jan 1, 1992·Annals of Neurology·D B CalneC Lee
Aug 1, 1974·The British Journal of Psychiatry : the Journal of Mental Science·D A Johnson, B B Heather
May 1, 1967·Neurology·M M Hoehn, M D Yahr
Dec 1, 1995·Nature Medicine·A AmadoriL Chieco-Bianchi
Apr 1, 1994·Acta Neurologica Scandinavica·C J O'NeillR J Dobbs
Sep 1, 1996·American Journal of Epidemiology·J W DavisD M Morens
Mar 28, 1998·Acta Neurologica Scandinavica·A CharlettS M Dobbs
Jul 23, 1999·Acta Neurologica Scandinavica·R J DobbsD W Peterson
Sep 6, 2000·Alimentary Pharmacology & Therapeutics·R J DobbsD W Peterson
Dec 20, 2000·The Journal of Infection·R J DobbsC Weller
Jan 4, 2001·Journal of Neuroimmunology·J BasE Buendia
Apr 17, 2001·International Journal of Cancer. Journal International Du Cancer·N M NielsenM Melbye
Oct 27, 2001·Archives of Neurology·K HisanagaY Iwasaki
Feb 15, 2002·The New England Journal of Medicine·Sudha SeshadriPhilip A Wolf
Apr 3, 2002·JAMA : the Journal of the American Medical Association·Nete Munk NielsenDorthe Askgaard
Nov 27, 2002·The American Journal of Psychiatry·Henning TiemeierMonique M B Breteler
May 9, 2003·Archives of Physical Medicine and Rehabilitation·Anne C GawneKathy S Wilson
Jul 10, 2003·Lancet Neurology·Ronald F Pfeiffer
Jun 5, 1965·The Medical Journal of Australia·R R STRANG
Apr 28, 2004·Autoimmunity Reviews·Yann Parel, Carlo Chizzolini
Sep 25, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Padraig E O'SuilleabhainRamon Diaz-Arrastia
Jun 21, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Sonja von CampenhausenRichard Dodel
Sep 13, 2005·Parkinsonism & Related Disorders·Yasuhiko BabaTatsuo Yamada
Jul 14, 2006·Epidemiology·Jørgen H OlsenKirsten Frederiksen
Jan 26, 2007·Diabetes Care·Gang HuJaakko Tuomilehto
May 9, 2007·Gastroenterology·Christian SchmeesMarkus Gerhard
Jun 15, 2007·Archives of Neurology·Angelika D WahnerBeate Ritz
Jul 24, 2007·Autoimmunity Reviews·Pietro Enea LazzeriniFranco Laghi Pasini

❮ Previous
Next ❯

Citations

Dec 3, 2014·Best Practice & Research. Clinical Gastroenterology·Jan Bornschein, Marcis Leja
Nov 26, 2010·Helicobacter·Natale FiguraAntonio Gasbarrini
Dec 30, 2011·Neuro-degenerative Diseases·R John DobbsIngvar T Bjarnason
Jun 5, 2019·Journal of Movement Disorders·Han-Lin Chiang, Chin-Hsien Lin
Sep 27, 2019·Frontiers in Medicine·Aisha D AugustinAndré Charlett
Feb 3, 2021·Annals of Neurology·Melanie P JensenUNKNOWN International Parkinson's Disease Genomics Consortium (IPDGC)

❮ Previous
Next ❯

Methods Mentioned

BETA
sandwich immunoassay
Enzyme-linked immunosorbent assay
biopsies
biopsy
ELISA

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

Antibodies: Complement Activation

The complement system can be activated by antigen-associated antibody. In the classical pathway of complement activation, C1q, C4b, and C3b are all able to bind to the Fc portion of IgG or IgM. Find the latest research on antibodies and complement activation here.

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.