Abstract
For blood progenitor cell (BPC) mobilization, standard-dose VIP chemotherapy consisting of etoposide, ifosfamide and cisplatin has previously shown effective tumor reduction in solid tumor patients and sufficient progenitor cell mobilization for autologous blood cell transplantation. Mobilization chemotherapy regimens in multiple myeloma (MM) predominantly consist of melphalan or cyclophosphamide that induce marked cytopenia and considerable variability of progenitor cell collection. We studied whether in MM (n = 13), BPCs were efficiently and reproducibly mobilized with etoposide (500 mg/m2) and ifosfamide (1500 mg/m2), followed by daily s.c. G-CSF (5 micrograms/kg). In parallel, patients with solid tumors or non-Hodgkin's lymphomas (n = 28) treated with etoposide (500 mg/m2), ifosfamide (1500 mg/m2) and cisplatin (150 mg/m2) and identical dosing of G-CSF were analyzed. Before chemotherapy (day 0), on day 7 after chemotherapy and on days of leukapheresis (day 9-14), leukocyte numbers, mononuclear cells (MNCs), CD34+ cells and coexpression of lineage markers were analyzed. Median blood leukocyte numbers were 28,100/microliters (range, 19,600-40,400) on day 10 in myeloma patients and progressively declined over the next 4 days. ...Continue Reading
Citations
Apr 27, 2000·Experimental Hematology·J O OjeifoK R Meehan
Nov 25, 2005·Leukemia·Y GuoM Lübbert
Sep 24, 1999·Leukemia & Lymphoma·F B Hagemeister
Jun 1, 2010·Leukemia & Lymphoma·Monika EngelhardtAntonio Palumbo
Jul 5, 2001·Hematological Oncology·M ArlandH G Höffkes
Aug 10, 2012·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Caroline Pinto Rebello LacativaAngelo Maiolino
Jul 11, 2009·Journal of Clinical Apheresis·Paola ColucciaFernando Ravagnani
Feb 3, 2012·Journal of Clinical Apheresis·Xiaohong HanYuankai Shi
Jul 4, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ulrich DenzMonika Engelhardt
Jun 20, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K Moeremans, L Annemans
Sep 21, 2007·Cytotherapy·M PutkonenK Remes
Jan 14, 2017·Leukemia & Lymphoma·Christine GreilRalph Wäsch
Jul 4, 2017·British Journal of Haematology·Johannes M WaldschmidtMonika Engelhardt
Apr 21, 2004·Annals of Plastic Surgery·Jeffrey S IsenbergJohn O Ojeifo
Aug 5, 2000·Bone Marrow Transplantation·A AltésJ Sierra
Aug 18, 2001·Bone Marrow Transplantation·S BilgramiP J Tutschka
Jun 26, 2002·Oncogene·Karen L MacKenzieMalcolm A S Moore
Feb 19, 2002·Oncogene·Junko H OhyashikiKazuma Ohyashiki
Feb 19, 2002·Oncogene·Satoru Kyo, Masaki Inoue
Jul 20, 2002·Blood·David A HessMickie Bhatia
Jul 21, 2009·European Journal of Haematology·Martina KleberMonika Engelhardt
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M EngelhardtJ Finke
May 9, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M R NowrousianS Seeber