Abstract
Patients with ventricular assist devices still suffer from high rates of adverse events. Since many of these complications are linked to the flow field within the pump, optimization of the device geometry is essential. To investigate design aspects that influence the flow field, we developed a centrifugal blood pump using industrial guidelines. We then systematically varied selected design parameters and investigated their effects on hemodynamics and hydraulic performance using computational fluid dynamics. We analysed the flow fields based on Eulerian and Lagrangian features, shear stress histograms and six indicators of hemocompatibility. Within the investigated range of clearance gaps (50-500 µm), number of impeller blades (4-7), and semi-open versus closed shroud design, we found association of potentially damaging shear stress conditions with larger gap size and more blades. The extent of stagnation and recirculation zones was reduced with lower numbers of blades and a semi-open impeller, but it was increased with smaller clearance. The Lagrangian hemolysis index, a metric commonly applied to estimate blood damage, showed a negative correlation with hydraulic efficiency and no correlation with the Eulerian threshold-based ...Continue Reading
References
Jan 1, 1980·Biorheology·G Heuser, R Opitz
Sep 1, 1994·Annals of Biomedical Engineering·J D Hellums
Jul 1, 1995·Artificial Organs·C Bludszuweit
Aug 29, 2002·Artificial Organs·W K ChanS C M Yu
Sep 24, 2004·Artificial Organs·Arash ArvandHelmut Reul
Oct 27, 2004·Artificial Organs·André Garon, Marie-Isabelle Farinas
Jan 28, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Pramote HochareonSteven Deutsch
Dec 3, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jingchun WuHarvey S Borovetz
Jun 27, 2008·Journal of Biomechanics·Matteo NobiliAlberto Redaelli
Jul 4, 2008·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·J F AntakiM V Kameneva
May 29, 2009·Artificial Organs·Nahn Ju KimJames F Antaki
Jun 16, 2009·Journal of Biomechanics·Umberto MorbiducciAlberto Redaelli
Oct 17, 2009·Artificial Organs·Jingchun WuJames F Antaki
Feb 5, 2010·Annals of Biomedical Engineering·D BluesteinK B Manning
Nov 16, 2010·Medical Engineering & Physics·Katharine H FraserZhongjun J Wu
May 29, 2012·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·M Ertan TaskinZhongjun J Wu
Sep 4, 2012·Journal of Biomechanical Engineering·Katharine H FraserZhongjun J Wu
Dec 4, 2012·IEEE Transactions on Bio-medical Engineering·Gregor OchsnerLino Guzzella
Apr 30, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jan D SchmittoAxel Haverich
Aug 4, 2015·Artificial Organs·Bente ThamsenUlrich Kertzscher
Nov 2, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·James K KirklinJames B Young
Nov 4, 2015·Artificial Organs·Hai YuDominique Thévenin
Dec 5, 2015·Artificial Organs·Roland GraefeUlrich Steinseifer
May 5, 2016·Blood·Angelo NascimbeneJing-Fei Dong
Jun 4, 2016·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Theodosios KorakianitisSahand Mozafari
Dec 30, 2016·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Sahand MozafariTheodosios Korakianitis
Citations
Jun 15, 2018·The International Journal of Artificial Organs·Benjamin TornerFrank-Hendrik Wurm
Aug 22, 2018·Artificial Organs·Lena WiegmannVartan Kurtcuoglu
Oct 4, 2018·Artificial Organs·Behnam GhadimiNasim Naderi
Oct 26, 2018·The International Journal of Artificial Organs·Matteo SelmiFilippo Consolo
Jul 23, 2019·The International Journal of Artificial Organs·Benjamin TornerFrank-Hendrik Wurm
Jul 4, 2019·Artificial Organs·Vikas KannojiyaPrasanta Kumar Das
Jul 2, 2020·The International Journal of Artificial Organs·A WisniewskiB Torner
Oct 28, 2019·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jiheum ParkPramod Bonde
Sep 23, 2020·The International Journal of Artificial Organs·Zheqin YuBin Guo
Aug 1, 2020·Artificial Organs·Yang ZhouChang Cui
Oct 10, 2018·Artificial Organs·Giulia LuraghiFrancesco Migliavacca
Nov 27, 2019·Annals of Biomedical Engineering·Bethany Rowson, Stefan M Duma
May 16, 2020·Cardiovascular Engineering and Technology·Peng FangShunzhou Yu
Apr 22, 2020·The International Journal of Artificial Organs·Peng FangShunzhou Yu
Aug 3, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jiheum ParkPramod Bonde
Dec 19, 2020·International Journal for Numerical Methods in Biomedical Engineering·Benjamin TornerHendrik Wurm
Aug 3, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Kai Von Petersdorff-CampenMarianne Schmid Daners
Feb 26, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Kai von Petersdorff-CampenMarianne Schmid Daners
Mar 27, 2021·Cardiovascular Engineering and Technology·Clayton S SemenzinGeoff Tansley
Apr 23, 2021·International Journal for Numerical Methods in Biomedical Engineering·Marco MartinolliChristian Vergara
Jun 16, 2021·The International Journal of Artificial Organs·Ahmet OnderMete Kalyoncu
Jul 6, 2021·Frontiers in Physiology·Peng WuShu Li
Sep 4, 2021·The International Journal of Artificial Organs·Jia-Dong HuoWei-Tao Wu
Sep 29, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Carsten StrauchMarcus Granegger