Blood Pump Design Variations and Their Influence on Hydraulic Performance and Indicators of Hemocompatibility

Annals of Biomedical Engineering
L WiegmannV Kurtcuoglu

Abstract

Patients with ventricular assist devices still suffer from high rates of adverse events. Since many of these complications are linked to the flow field within the pump, optimization of the device geometry is essential. To investigate design aspects that influence the flow field, we developed a centrifugal blood pump using industrial guidelines. We then systematically varied selected design parameters and investigated their effects on hemodynamics and hydraulic performance using computational fluid dynamics. We analysed the flow fields based on Eulerian and Lagrangian features, shear stress histograms and six indicators of hemocompatibility. Within the investigated range of clearance gaps (50-500 µm), number of impeller blades (4-7), and semi-open versus closed shroud design, we found association of potentially damaging shear stress conditions with larger gap size and more blades. The extent of stagnation and recirculation zones was reduced with lower numbers of blades and a semi-open impeller, but it was increased with smaller clearance. The Lagrangian hemolysis index, a metric commonly applied to estimate blood damage, showed a negative correlation with hydraulic efficiency and no correlation with the Eulerian threshold-based ...Continue Reading

References

Jan 1, 1980·Biorheology·G Heuser, R Opitz
Sep 1, 1994·Annals of Biomedical Engineering·J D Hellums
Oct 27, 2004·Artificial Organs·André Garon, Marie-Isabelle Farinas
Jan 28, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Pramote HochareonSteven Deutsch
Dec 3, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jingchun WuHarvey S Borovetz
Jul 4, 2008·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·J F AntakiM V Kameneva
Feb 5, 2010·Annals of Biomedical Engineering·D BluesteinK B Manning
Nov 16, 2010·Medical Engineering & Physics·Katharine H FraserZhongjun J Wu
May 29, 2012·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·M Ertan TaskinZhongjun J Wu
Dec 4, 2012·IEEE Transactions on Bio-medical Engineering·Gregor OchsnerLino Guzzella
Apr 30, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jan D SchmittoAxel Haverich
Nov 2, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·James K KirklinJames B Young
Jun 4, 2016·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Theodosios KorakianitisSahand Mozafari
Dec 30, 2016·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Sahand MozafariTheodosios Korakianitis

❮ Previous
Next ❯

Citations

Oct 26, 2018·The International Journal of Artificial Organs·Matteo SelmiFilippo Consolo
Jul 23, 2019·The International Journal of Artificial Organs·Benjamin TornerFrank-Hendrik Wurm
Jul 2, 2020·The International Journal of Artificial Organs·A WisniewskiB Torner
Oct 28, 2019·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jiheum ParkPramod Bonde
Sep 23, 2020·The International Journal of Artificial Organs·Zheqin YuBin Guo
Nov 27, 2019·Annals of Biomedical Engineering·Bethany Rowson, Stefan M Duma
Apr 22, 2020·The International Journal of Artificial Organs·Peng FangShunzhou Yu
Aug 3, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jiheum ParkPramod Bonde
Dec 19, 2020·International Journal for Numerical Methods in Biomedical Engineering·Benjamin TornerHendrik Wurm
Aug 3, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Kai Von Petersdorff-CampenMarianne Schmid Daners
Feb 26, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Kai von Petersdorff-CampenMarianne Schmid Daners
Mar 27, 2021·Cardiovascular Engineering and Technology·Clayton S SemenzinGeoff Tansley
Apr 23, 2021·International Journal for Numerical Methods in Biomedical Engineering·Marco MartinolliChristian Vergara
Jun 16, 2021·The International Journal of Artificial Organs·Ahmet OnderMete Kalyoncu
Sep 4, 2021·The International Journal of Artificial Organs·Jia-Dong HuoWei-Tao Wu
Sep 29, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Carsten StrauchMarcus Granegger

❮ Previous
Next ❯

Software Mentioned

SPWVI
mathop
SPSS Statistics
StarCCM +

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.