Blood purification by nonselective hemoadsorption prevents death after traumatic brain injury and hemorrhagic shock in rats

The Journal of Trauma and Acute Care Surgery
Todd O McKinleyRichard B Rodgers

Abstract

Patients who sustain traumatic brain injury (TBI) and concomitant hemorrhagic shock (HS) are at high risk of high-magnitude inflammation which can lead to poor outcomes and death. Blood purification by hemoadsorption (HA) offers an alternative intervention to reduce inflammation after injury. We tested the hypothesis that HA would reduce mortality in a rat model of TBI and HS. Male Sprague Dawley rats were subjected to a combined injury of a controlled cortical impact to their brain and pressure-controlled HS. Animals were subsequently instrumented with an extracorporeal blood circuit that passed through a cartridge for sham or experimental treatment. In experimental animals, the treatment cartridge was filled with proprietary beads (Cytosorbents, Monmouth Junction, NJ) that removed circulating molecules between 5 kDa and 60 kDa. Sham rats had equivalent circulation but no blood purification. Serial blood samples were analyzed with multiplex technology to quantify changes in a trauma-relevant panel of immunologic mediators. The primary outcome was survival to 96 hours postinjury. Hemoadsorption improved survival from 47% in sham-treated rats to 86% in HA-treated rats. There were no treatment-related changes in histologic appear...Continue Reading

References

Mar 23, 2005·Lancet·Martin Edwards
Nov 7, 2007·Journal of Neuropathology and Experimental Neurology·Brian Joseph KelleyJohn Theodore Povlishock
Apr 25, 2008·Critical Care Medicine·Zhi-Yong PengJohn A Kellum
Aug 12, 2008·Journal of Neurotrauma·J Humberto Tapia-PerezJuan Chalita-Williams
Feb 23, 2010·Immunopharmacology and Immunotoxicology·Yoram VodovotzGary An
Aug 11, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Joanna Szmydynger-ChodobskaAdam Chodobski
Mar 1, 2012·Journal of Neurotrauma·Deborah M SteinThomas M Scalea
Mar 14, 2012·Critical Care : the Official Journal of the Critical Care Forum·Luisa CorralRafael Mañez
Oct 16, 2012·Journal of Neuroinflammation·Mahasweta DasShyam S Mohapatra
Mar 28, 2013·Critical Care : the Official Journal of the Critical Care Forum·Thomas RimmeléJohn A Kellum
Feb 27, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Adel HelmyPeter J Hutchinson
Jul 25, 2014·JAMA : the Journal of the American Medical Association·Claudia S RobertsonPaul Swank
Dec 11, 2014·The New England Journal of Medicine·David W WrightUNKNOWN NETT Investigators
Feb 7, 2015·The International Journal of Artificial Organs·Frank BruengerJan F Gummert
Apr 4, 2015·Blood Purification·Jicheng ZhangJohn A Kellum
Jun 20, 2015·The Journal of Trauma and Acute Care Surgery·Brandon W BondsDeborah M Stein
Jun 27, 2015·Experimental Neurology·Peter J Bergold
Apr 10, 2016·Critical Care : the Official Journal of the Critical Care Forum·Martin H BernardiAndreas Spittler
Apr 16, 2016·The International Journal of Artificial Organs·Dana R TomescuIrinel Popescu
May 4, 2016·The International Journal of Artificial Organs·Karl TrägerHelmut Reinelt
Nov 30, 2016·Critical Care Clinics·Angela SauaiaErnest E Moore
Mar 28, 2017·Critical Care : the Official Journal of the Critical Care Forum·Klaus KogelmannMatthias Drüner

❮ Previous
Next ❯

Citations

Jan 21, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Liang ShanZhi Ping Xu
Jan 30, 2021·Scientific Reports·Cynthia R MullerPedro Cabrales
Mar 7, 2021·International Journal of Molecular Sciences·Baptiste BalançaAnne-Claire Lukaszewicz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.