Blood Purification With CytoSorb in Critically Ill Patients: Single-Center Preliminary Experience

Artificial Organs
Maria Grazia CalabròFederico Pappalardo

Abstract

The CytoSorb adsorber, a blood purification therapy, is able to remove molecules in the 5-60 kDa range which comprises the majority of inflammatory mediators and some endogenous molecules. We aimed to evaluate CytoSorb therapy on clinical outcomes in critically ill patients. A retrospective case series study, from February 2016 to May 2017, was performed in 40 patients with multiple organ failure who received CytoSorb treatment. There were 28 patients with cardiogenic shock, 2 with septic shock, 9 with acute respiratory distress syndrome, and 1 with liver failure. Nineteen patients (47%) underwent extracorporeal membrane oxygenation, 11 (27%) had an intra-aortic balloon pump, 9 (22%) were implanted with Impella, 6 (15%) had a ventricular assist device, and 18 (45%) were treated with continuous veno-venous hemofiltration. After CytoSorb treatment, total bilirubin decreased from 11.6 ± 9.2 to 6.8 ± 5.1 mg/dL (P = 0.005), lactate from 12.1 ± 8.7 to 2.9 ± 2.5 mmol/L (P < 0.001), CPK from 2416 (670-8615) to 281 (44-2769) U/L (P < 0.001) and LDH from 1230 (860-3157) to 787 (536-1148) U/L (P < 0.001). The vasoactive-inotropic score after 48 h of treatment was reduced to 10 points, P = 0.009. Thirty-day mortality was 55% and ICU mortal...Continue Reading

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Citations

Jan 23, 2020·Artificial Organs·Paul S Malchesky
Dec 24, 2019·The International Journal of Artificial Organs·Karl TrägerThomas Datzmann
Jun 26, 2020·Medizinische Klinik, Intensivmedizin und Notfallmedizin·C G Krenn, H Steltzer
Jul 6, 2019·Frontiers in Cardiovascular Medicine·Achim LotherDaniel Duerschmied
Jan 23, 2020·Scientific Reports·Karl-Gustav RuggebergMaryann C Gruda
Dec 12, 2020·The International Journal of Artificial Organs·Dana TomescuSimona Dima
Dec 4, 2020·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Mihai PopescuDana Tomescu
Nov 13, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Marina RiederAlexander Supady
Feb 26, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Marina RiederAlexander Supady
Mar 10, 2021·Artificial Organs·Anna Mara ScandroglioFederico Pappalardo
Oct 19, 2020·Journal of Cardiothoracic and Vascular Anesthesia·Alessandro BellettiGiovanni Landoni
Oct 28, 2021·The International Journal of Artificial Organs·Marina PieriAnna M Scandroglio
Feb 16, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Daniel ZicklerJan Matthias Kruse
Oct 19, 2021·Epidemiology and Infection·Peng XieMaolong Dong
Apr 23, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Alexander SupadyDaniel Duerschmied

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