Blood pyrrole-protein adducts as a diagnostic and prognostic index in pyrrolizidine alkaloid-hepatic sinusoidal obstruction syndrome

Drug Design, Development and Therapy
Hong GaoJi Yao Wang

Abstract

The diagnosis of hepatic sinusoidal obstruction syndrome (HSOS) induced by pyrrolizidine alkaloids is mainly based on clinical investigation. There is currently no prognostic index. This study evaluated the quantitative measurement of blood pyrrole-protein adducts (PPAs) as a diagnostic and prognostic index for pyrrolizidine alkaloid-induced HSOS. Suspected drug-induced liver injury patients were prospectively recruited. Blood PPAs were quantitatively measured using ultra-performance liquid chromatography-tandem mass spectrometry. Patients' age, sex, biochemistry test results, and a detailed drug history were recorded. The patients were divided into two groups, ie, those with HSOS induced by pyrrolizidine alkaloid-containing drugs and those with liver injury induced by drugs without pyrrolizidine alkaloids. The relationship between herb administration, clinical outcomes, blood sampling time, and blood PPA concentration in pyrrolizidine alkaloid-associated HSOS patients was analyzed using multiple linear regression analysis. Forty patients met the entry criteria, among whom 23 had pyrrolizidine alkaloid-associated HSOS and 17 had liver injury caused by drugs without pyrrolizidine alkaloids. Among the 23 patients with pyrrolizidi...Continue Reading

Citations

Jan 23, 2019·Journal of Gastroenterology and Hepatology·Yuzheng ZhugeUNKNOWN Chinese Society of Gastroenterology Committee of Hepatobiliary Disease
Jan 21, 2018·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Xia LiHui Wang
Mar 28, 2017·Gut·Gerd A Kullak-UblickGuruprasad P Aithal
Jul 7, 2018·Journal of Food and Drug Analysis·Jiang MaGe Lin
Aug 25, 2020·Journal of Clinical and Translational Hepatology·Rolf TeschkeJing Jing
Mar 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Li-Hua ChenJian-Yong Si
May 19, 2021·Archives of Toxicology·Yisheng HeGe Lin
Jul 6, 2021·Journal of Clinical and Translational Hepatology·Wei ZhangYuzheng Zhuge
Jun 22, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xinmeng ChenGe Lin
Jul 28, 2021·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Li GuoBaojian Wu

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Methods Mentioned

BETA
biopsy

Software Mentioned

Statistical Package for the Social Sciences

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