Blood residence time to assess significance of coronary artery stenosis.

Scientific Reports
Javad HashemiR Eric Berson

Abstract

Coronary artery stenosis is a narrowing of coronary lumen space caused by an atherosclerotic lesion. Fractional flow reserve (FFR) is the gold standard metric to assess physiological significance of coronary stenosis, but requires an invasive procedure. Computational modeling in conjunction with patient-specific imaging demonstrates formation of regions of recirculatory flow distal to a stenosis, increasing mean blood residence time relative to uninhibited flow. A new computational parameter, mean blood residence time (BloodRT), was computed for 100 coronary artery segments for which FFR was known. A threshold for BloodRT was determined to assess the physiological significance of a stenosis, analogous to diagnostic threshold for FFR. Model sensitivity and specificity of BloodRT for diagnosis of hemodynamically significant coronary stenosis was 98% and 96% respectively, compared with FFR. When applied to clinical practice, this could potentially allow practicing cardiologists to accurately assess the severity of coronary stenosis without resorting to invasive techniques.

References

Aug 1, 1995·Journal of the American College of Cardiology·J BartúnekB De Bruyne
May 1, 1996·Journal of Biomechanical Engineering·M J KunovC R Ethier
Jun 17, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Nobuhiro TanakaAkira Yamashina
Jan 13, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Heather A HimburgMorton H Friedman
Feb 16, 2006·Annals of Biomedical Engineering·Jonghwun JungRobert W Lyczkowski
Mar 28, 2007·The New England Journal of Medicine·William E BodenUNKNOWN COURAGE Trial Research Group
May 29, 2007·Journal of the American College of Cardiology·Nico H J PijlsBernard de Bruyne
Jan 16, 2009·The New England Journal of Medicine·Pim A L ToninoUNKNOWN FAME Study Investigators
Jun 9, 2009·The New England Journal of Medicine·UNKNOWN BARI 2D Study GroupBurton E Sobel
Jan 18, 2011·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Michael MarklTino Ebbers
Mar 22, 2014·Current Cardiology Reports·Ryo NakazatoJames K Min
Jan 30, 2015·International Journal for Numerical Methods in Biomedical Engineering·Jun-Mei ZhangLiang Zhong
Jun 29, 2015·JACC. Cardiovascular Interventions·Paul D MorrisJulian P Gunn
Aug 20, 2016·Biomechanics and Modeling in Mechanobiology·Bruno GuerciottiRoberto Scrofani
Oct 20, 2017·PloS One·Hyeonji HongKyung Chun Kim
Feb 1, 2019·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee

❮ Previous
Next ❯

Citations

May 21, 2021·Frontiers in Physiology·Javad HashemiGhassan S Kassab

❮ Previous
Next ❯

Software Mentioned

ANSYS Fluent
ANSYS Fluent solver
ANSYS Mesher

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.