Blood viscosity is an important determinant of local flow characteristics, which exhibits shear thinning behavior: it decreases exponentially with increasing shear rates. Both hematocrit and plasma viscosity influence blood viscosity. The shear thinning property of blood is mainly attributed to red blood cell (RBC) rheological properties. RBC aggregation occurs at low shear rates, and increases blood viscosity and depends on both cellular (RBC aggregability) and plasma factors. Blood flow in the microcirculation is highly dependent on the ability of RBC to deform, but RBC deformability also affects blood flow in the macrocirculation since a loss of deformability causes a rise in blood viscosity. Indeed, any changes in one or several of these parameters may affect blood viscosity differently. Poiseuille's Law predicts that any increase in blood viscosity should cause a rise in vascular resistance. However, blood viscosity, through its effects on wall shear stress, is a key modulator of nitric oxide (NO) production by the endothelial NO-synthase. Indeed, any increase in blood viscosity should promote vasodilation. This is the case in healthy individuals when vascular function is intact and able to adapt to blood rheological strai...Continue Reading
The red cell as a fluid droplet: tank tread-like motion of the human erythrocyte membrane in shear flow
The changes in hematocrit, hemoglobin, plasma volume and proteins during and after different types of exercise
Decreased hydrodynamic resistance in the two-phase flow of blood through small vertical tubes at low flow rates
Erythrocyte deformability and segmental pulmonary vascular resistance: osmolarity and heat treatment
Exercise performance, red blood cell deformability, and lipid peroxidation: effects of fish oil and vitamin E
Capillary recruitment in response to tissue hypoxia and its dependence on red blood cell deformability
Time course of hemorheological alterations after heavy anaerobic exercise in untrained human subjects
Does exercise-induced hypoxemia modify lactate influx into erythrocytes and hemorheological parameters in athletes?
Elevated plasma viscosity in extreme hemodilution increases perivascular nitric oxide concentration and microvascular perfusion
Effect of antioxidant vitamin treatment on the time course of hematological and hemorheological alterations after an exhausting exercise episode in human subjects
Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes
Red blood cell aggregation, aggregate strength and oxygen transport potential of blood are abnormal in both homozygous sickle cell anemia and sickle-hemoglobin C disease
Blood pressure directly correlates with blood viscosity in diabetes type 1 children but not in normals
Decreased sickle red blood cell adhesion to laminin by hydroxyurea is associated with inhibition of Lu/BCAM protein phosphorylation
Effects of hydration and dehydration on blood rheology in sickle cell trait carriers during exercise
Hemorheology and exercise: effects of warm environments and potential consequences for sickle cell trait carriers
Differential modulation of adhesion molecule expression by hydroxycarbamide in human endothelial cells from the micro- and macrocirculation: potential implications in sickle cell disease vasoocclusive events
Mild haemorheological changes induced by a moderate endurance exercise in patients with sickle cell anaemia
Frequency of pain crises in sickle cell anemia and its relationship with the sympatho-vagal balance, blood viscosity and inflammation
Delayed beneficial effect of acute exercise on red blood cell aggregate strength in patients with sickle cell anemia
Hemolysis induced by an extreme mountain ultra-marathon is not associated with a decrease in total red blood cell volume
Effects of hydration and water deprivation on blood viscosity during a soccer game in sickle cell trait carriers
Hemorheological risk factors of acute chest syndrome and painful vaso-occlusive crisis in children with sickle cell disease
Erythrocyte density in sickle cell syndromes is associated with specific clinical manifestations and hemolysis.
Autoregulation and mechanotransduction control the arteriolar response to small changes in hematocrit
Increased blood viscosity and red blood cell aggregation in a patient with sickle cell anemia and smoldering myeloma
Erythrocyte microparticles can induce kidney vaso-occlusions in a murine model of sickle cell disease.
Moderate exercise promotes human RBC-NOS activity, NO production and deformability through Akt kinase pathway
Hematologic and hemorheological determinants of resting and exercise-induced hemoglobin oxygen desaturation in children with sickle cell disease
Is there a relationship between the hematocrit-to-viscosity ratio and microvascular oxygenation in brain and muscle?
Prior exposure of endothelial cells to hydroxycarbamide alters the flow dynamics and adhesion of sickle red blood cells
Alpha thalassemia protects sickle cell anemia patients from macro-albuminuria through its effects on red blood cell rheological properties
Decreased hematocrit-to-viscosity ratio and increased lactate dehydrogenase level in patients with sickle cell anemia and recurrent leg ulcers
Hydroxycarbamide decreases sickle reticulocyte adhesion to resting endothelium by inhibiting endothelial lutheran/basal cell adhesion molecule (Lu/BCAM) through phosphodiesterase 4A activation.
Moderate endurance exercise in patients with sickle cell anaemia: effects on oxidative stress and endothelial activation
Impaired oxygen uptake efficiency slope and off-transient kinetics of pulmonary oxygen uptake in sickle cell anemia are associated with hemorheological abnormalities
Effects of moderate aerobic exercise training on hemorheological and laboratory parameters in ischemic heart disease patients
Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease.
Reduced fitness and abnormal cardiopulmonary responses to maximal exercise testing in children and young adults with sickle cell anemia
Hydroxyurea treatment does not increase blood viscosity and improves red blood cell rheology in sickle cell anemia
Which side of the balance determines the frequency of vaso-occlusive crises in children with sickle cell anemia: Blood viscosity or microvascular dysfunction?
Increases in core temperature counterbalance effects of haemoconcentration on blood viscosity during prolonged exercise in the heat
Extracellular microvesicle microRNAs in children with sickle cell anaemia with divergent clinical phenotypes
Effect of Age on Blood Rheology in Sickle Cell Anaemia and Sickle Cell Haemoglobin C Disease: A Cross-Sectional Study
The relationship between hemorheological parameters and mortality in critically ill patients with and without sepsis
Albuminuria Is Associated with Endothelial Dysfunction and Elevated Plasma Endothelin-1 in Sickle Cell Anemia
Alpha-thalassaemia promotes frequent vaso-occlusive crises in children with sickle cell anaemia through haemorheological changes
Association between oxidative stress and vascular reactivity in children with sickle cell anaemia and sickle haemoglobin C disease
Plasmapheresis may improve clinical condition in sickle cell disease through its effects on red blood cell rheology
Endurance training reduces exercise-induced acidosis and improves muscle function in a mouse model of sickle cell disease
Eryptosis and hemorheological responses to maximal exercise in athletes: Comparison between running and cycling
Deformability of different red blood cell populations and viscosity of differently trained young men in response to intensive and moderate running
Exercise capacity and clinical outcomes in adults followed in the Cooperative Study of Sickle Cell Disease (CSSCD)
Moderate-intensity endurance-exercise training in patients with sickle-cell disease without severe chronic complications (EXDRE): an open-label randomised controlled trial
New insights into red cell rheology and adhesion in patients with sickle cell anaemia during vaso-occlusive crises
Red blood cell aggregation, disaggregation and aggregate morphology in autologous plasma and serum in diabetic foot disease
Impact of surface-area-to-volume ratio, internal viscosity and membrane viscoelasticity on red blood cell deformability measured in isotonic condition
Effect of acute exercise on RBC deformability and RBC nitric oxide synthase signalling pathway in young sickle cell anaemia patients
Effects of Individualized Treadmill Endurance Training on Oxidative Stress in Skeletal Muscles of Transgenic Sickle Mice
Red Blood Cell-Mediated S-Nitrosohemoglobin-Dependent Vasodilation: Lessons Learned from a β-Globin Cys93 Knock-in Mouse
The physiological role of plasma and its components and the clinical implications of different methods of apheresis. A narrative review
Single-cell O2 exchange imaging shows that cytoplasmic diffusion is a dominant barrier to efficient gas transport in red blood cells
Twelve Weeks of Combined Resistance and Aerobic Exercise Improves Cardiometabolic Biomarkers and Enhances Red Blood Cell Hemorheological Function in Obese Older Men: A Randomized Controlled Trial
Patient and haemodynamic factors affecting intraoperative graft flow during coronary artery bypass grafting: an observational pilot study
Surface area-to-volume ratio, not cellular viscoelasticity, is the major determinant of red blood cell traversal through small channels
A comprehensive review of hydroxyurea for β-haemoglobinopathies: the role revisited during COVID-19 pandemic.
Microfluidics in Sickle Cell Disease Research: State of the Art and a Perspective Beyond the Flow Problem.
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