Blood spots as an alternative to whole blood collection and the effect of a small monetary incentive to increase participation in genetic association studies.

BMC Medical Research Methodology
Parveen BhattiAlice J Sigurdson

Abstract

Collection of buccal cells from saliva for DNA extraction offers a less invasive and convenient alternative to venipuncture blood collection that may increase participation in genetic epidemiologic studies. However, dried blood spot collection, which is also a convenient method, offers a means of collecting peripheral blood samples from which analytes in addition to DNA can be obtained. To determine if offering blood spot collection would increase participation in genetic epidemiologic studies, we conducted a study of collecting dried blood spot cards by mail from a sample of female cancer cases (n = 134) and controls (n = 256) who were previously selected for a breast cancer genetics study and declined to provide a venipuncture blood sample. Participants were also randomized to receive either a $2.00 bill or no incentive with the blood spot collection kits. The average time between the venipuncture sample refusal and recruitment for the blood spot collection was 4.4 years. Thirty-seven percent of cases and 28% of controls provided a dried blood spot card. While the incentive was not associated with participation among controls (29% for $2.00 incentive vs. 26% for no incentive, p = 0.6), it was significantly associated with par...Continue Reading

References

Jan 1, 1997·Epidemiologic Reviews·K K SteinbergE J Sampson
Jul 15, 1998·American Journal of Epidemiology·E Gilbart, N Kreiger
May 8, 2001·The Journal of Nutrition·J V MeiW H Hannon
Apr 20, 2002·Epidemiology·Karen SteinbergEric Sampson
Apr 4, 2003·American Journal of Epidemiology·Michele Morin DoodyMartha S Linet
Jun 5, 2003·Cancer·Alice J SigurdsonMartha S Linet
Jul 20, 2004·American Journal of Epidemiology·Patricia F Coogan, Lynn Rosenberg
Sep 4, 2007·International Journal of Cancer. Journal International Du Cancer·Parveen BhattiAlice J Sigurdson
Apr 10, 2008·Journal of Exposure Science & Environmental Epidemiology·Sanwat N ChaudhuriUNKNOWN Rocky Mountain Biomonitoring Consortium
Jul 7, 2009·BMC Genomics·Mads V HollegaardDavid M Hougaard
Nov 19, 2010·Bioanalysis·Joanne V MeiW Harry Hannon

❮ Previous
Next ❯

Citations

May 9, 2012·BMC Medical Research Methodology·Ana P NunesFernando C Barros
Jun 21, 2014·Journal of Community Genetics·Carla L StorrNicholas Ialongo
Apr 6, 2012·Epilepsy Research·Sylwia Misiewicz, Melodie R Winawer
Jul 15, 2015·BMC Clinical Pathology·Claudio A MastronardiGilberto Paz-Filho
Dec 3, 2013·Placenta·G J BurtonC W Redman
Apr 11, 2017·Critical Reviews in Clinical Laboratory Sciences·Sylvain LehmannChristophe Hirtz
May 17, 2015·Clinical Chemistry·Christina Ellervik, Jim Vaught

❮ Previous
Next ❯

Methods Mentioned

BETA
blood collection
blood spot collection
blood draw

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Genetics in Medicine : Official Journal of the American College of Medical Genetics
David KaufmanKathy Hudson
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Tove Rylander-RudqvistAlicja Wolk
© 2022 Meta ULC. All rights reserved