Blood stream infections of abdominal origin in the intensive care unit: characteristics and determinants of death

Surgical Infections
Jan J De WaeleStijn I Blot

Abstract

Blood stream infections (BSI) of abdominal origin are associated with a high mortality rate. We hypothesized that both patient and microbiological factors determine death in critically ill patients who develop such infections. Ninety-six consecutive patients who developed BSI of abdominal origin in an 11-year period (1992-2002) in the intensive care unit (ICU) of the Ghent University Hospital were studied. Patient data were retrieved from a prospective registry of BSI. Demographics, disease severity, source of the BSI, incidence of organ failure, and outcome were recorded. Microbiological data were retrieved from the patient file and the hospital laboratory. Secondary peritonitis and intra-abdominal abscesses were the source of the BSI in the majority of patients. The majority of the organisms involved were gram-negative, with Escherichia coli isolated most frequently. Twenty-one patients (22%) had polymicrobial BSI, and in 39 patients, at least one of the micro-organisms was antibiotic resistant (41%). The mortality rate in the whole patient group was 62.5% (60/96), which was significantly higher than the Acute Physiology and Chronic Health Evaluation (APACHE) II-based expected mortality rate (p < 0.001). Patients who died wer...Continue Reading

References

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Citations

Dec 26, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joseph S SolomkinJohn G Bartlett
Jul 8, 2018·Critical Care : the Official Journal of the Critical Care Forum·Adel AlqarniPhilippe Montravers
Jun 13, 2015·Surgical Infections·Christopher A GuidryRobert G Sawyer
Sep 13, 2008·Current Opinion in Critical Care·Stijn BlotDirk Vogelaers
Jul 14, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Stephen B PruettXiaomin Deng
Jun 12, 2013·Journal of Intensive Care Medicine·Ann-Kristin U Friedrich, Mitchell Cahan
Dec 10, 2015·Critical Care Medicine·Kai SingbartlJohn A Kellum
Aug 13, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Anthony Bonavia, Kai Singbartl
Nov 29, 2014·BMC Infectious Diseases·Jean-François TimsitMichel Wolff
Mar 30, 2017·Surgical Infections·Josep BallusJoan A Roncal
Feb 26, 2011·Surgical Infections·Osarumwense D Osifo, Scott O Ogiemwonyi
May 27, 2021·Drugs·Dirk VogelaersUNKNOWN Abdominal Sepsis Study (‘AbSeS’) Group on behalf of the Trials Group of the European Society of Intensive Care Medicine

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