PMID: 6978518Jan 1, 1982Paper

Blood T-lymphocyte functions in healthy adults in relation to age

Scandinavian Journal of Haematology
C WedelinH Mellstedt

Abstract

Blood T-lymphocyte functions were studied in 167 healthy adults (age range 19-91 years). Lymphocyte DNA synthesis induced by concanavalin A, pokeweed mitogen and PPD antigen declined with age while the spontaneous DNA synthesis remained essentially unchanged. Relative and total T-cell counts but not total lymphocyte counts were moderately decreased in elderly persons. The lymphocyte response to mitogens correlated with the PPD-induced activation in vitro. Lymphocyte and T-cell counts did not show any association with the response to mitogens and antigen. A few subjects were tested on several occasions during 2-7 years confirming a good reproducibility of the techniques employed. Thus ageing is associated with diminished number of T-cells and impairment of lymphocyte activation by T-cell mitogens and PPD antigen. The clinical importance of this general age-related T-cell deficiency remains largely unresolved.

References

May 1, 1978·Clinical Immunology and Immunopathology·H M HallgrenE J Yunis
Oct 1, 1977·Scandinavian Journal of Haematology·M BjörkholmH Mellsted
Jan 1, 1978·Clinical Immunology and Immunopathology·J P AntelB G Arnason
May 1, 1975·The American Journal of Medicine·E Diaz-JauanenR C Williams
Jan 1, 1975·Gerontologia·B FixaV Chmelar
Nov 18, 1972·Lancet·J F BachH Le Brigand
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Jan 1, 1982·British Journal of Cancer·C WedelinH Mellstedt
Feb 29, 1964·Lancet·A S COULSON, D G CHALMERS

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Citations

Mar 1, 1986·Environmental Health Perspectives·P O Ganrot
Jun 1, 1983·European Journal of Clinical Investigation·H M LokhorstG C de Gast
Jan 1, 1991·Journal of Clinical Apheresis·C R PriorP Jacobs
Apr 1, 1984·Journal of the American Geriatrics Society·J S ThompsonN Tietz
Feb 1, 1984·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·H NielsenS O Larsen
Sep 15, 1984·Cancer·M BjörkholmB Essy-Ehsing
Dec 1, 1989·Journal of the American Geriatrics Society·J CrawfordH J Cohen

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