Feb 1, 1990

Blood testosterone level: a season-dependent factor regulating immune reactivity in lizards

A H SaadR el Ridi


An attempt to study the interaction between testosterone (Ts) and the immune system of the lizard Chalcides ocellatus led to three major findings: 1) Endogenous serum Ts levels in both males and females peak in spring and are minimal during summer; 2) Injection of Ts in either male or female lizards induces significant depletion of lymphoid elements, reduction in serum antibody titers to rat erythrocytes and increase in skin allograft survival; 3) A distinct inverse correlation between endogenous serum Ts levels and lizard immunocompetence is observed from March to September. The data obtained strongly suggested that concentration of circulating Ts is a season-related factor that is critical in defining the immune profile of lizards.

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Mentioned in this Paper

Immune System
Testosterone Measurement
Chalcides ocellatus
Graft Survival
Antibody Titer Measurement
Seasonal Variation
Antibody Formation
Specimen Type - Erythrocytes

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