Blood urea nitrogen (BUN) independently predicts mortality in critically ill patients admitted to ICU: A multicenter study

Clinical Hemorheology and Microcirculation
Bernhard WernlyChristian Jung

Abstract

The Microcirculatory Shock Occurrence in Acutely Ill Patients (micro-SOAP) study investigated associations of microcirculation and mortality. Risk stratification in critically ill patients is of utmost interest. Established score such as APACHE2 (Acute Physiology And Chronic Health Evaluation 2) are relatively complex and might therefore be of limited use. Blood urea nitrogen (BUN) was described to be associated with mortality in various diseases. We therefore aimed (i) to evaluate BUN for prediction of mortality in a cohort of critically ill patients and (ii) to investigate associations of BUN with microcirculation. 412 patients were included in our post-hoc analysis of the prospective multicenter microSOAP study. Assesment of the sublingual microcirculation (Sidestream Dark Field (SDF) imaging) and collection of laboratory values were performed on the same day in this point prevalence study. Evaluation of associations with mortality was done by logistic regression analysis. An optimal BUN cut-off was calculated by means of the Youden Index. Median BUN was 9.0 mmol/L. BUN was associated with in-hospital-mortality in a logistic regression analysis (HR 1.03; 95% CI 1.01-1.05; p < 0.001). Per quartile (BUN 0-5.4 mmol/L, 5.4-9.0 m...Continue Reading

References

Nov 11, 2005·Critical Care : the Official Journal of the Critical Care Forum·E Christiaan BoermaCan Ince
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Jan 8, 2009·Intensive Care Medicine·Arnaldo DubinCan Ince
Apr 16, 2009·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Christian JungMarkus Ferrari
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Jun 19, 2009·Critical Care : the Official Journal of the Critical Care Forum·Arnaldo DubinCan Ince
Oct 24, 2009·Shock·Angeliki SpanosRupert M Pearse
Oct 27, 2009·The Annals of Thoracic Surgery·Daniel De BackerJean-Louis Vincent
Sep 11, 2010·Critical Care : the Official Journal of the Critical Care Forum·Christian JungMarkus Ferrari
Dec 25, 2010·Critical Care : the Official Journal of the Critical Care Forum·Andrea MorelliMartin Westphal
Mar 21, 2012·Critical Care Medicine·Vanina S Kanoore EdulArnaldo Dubin
Dec 25, 2012·Intensive Care Medicine·Andrius PranskunasE Christiaan Boerma
Aug 16, 2014·Critical Care Medicine·Namkje A R VellingaUNKNOWN microSOAP Study Group
Feb 28, 2015·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Christian JungHolger Thiele
Oct 19, 2017·Clinical Hemorheology and Microcirculation·Michael HesslerChristian Ertmer
Oct 20, 2017·Critical Care : the Official Journal of the Critical Care Forum·Namkje A R VellingaUNKNOWN microSOAP study group

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Citations

Sep 15, 2020·Clinical Hemorheology and Microcirculation·Raphael Romano BrunoChristian Jung
Nov 24, 2020·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Hong Joon ParkSanghyun Park
Mar 23, 2021·Clinical Nutrition ESPEN·Amanda Gomes PereiraMarcos Ferreira Minicucci
Mar 28, 2021·Clinical Nursing Research·Aiqun ZhuJingping Zhang

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