Blood viscosity maintains microvascular conditions during normovolemic anemia independent of blood oxygen-carrying capacity

American Journal of Physiology. Heart and Circulatory Physiology
Pedro CabralesAmy G Tsai

Abstract

Responses to exchange transfusion with red blood cells (RBCs) containing methemoglobin (MetRBC) were studied in an acute isovolemic hemodiluted hamster window chamber model to determine whether oxygen content participates in the regulation of systemic and microvascular conditions during extreme hemodilution. Two isovolemic hemodilution steps were performed with 6% dextran 70 kDa (Dex70) until systemic hematocrit (Hct) was reduced to 18% (Level 2). A third-step hemodilution reduced the functional Hct to 75% of baseline by using either a plasma expander (Dex70) or blood adjusted to 18% Hct with all MetRBCs. In vivo functional capillary density (FCD), microvascular perfusion, and oxygen distribution in microvascular networks were measured by noninvasive methods. Methylene blue was administered intravenously to reduce methemoglobin (rRBC), which increased oxygen content with no change in Hct or viscosity from MetRBC. Final blood viscosities after the entire protocol were 2.1 cP for Dex70 and 2.8 cP for MetRBC (baseline, 4.2 cP). MetRBC had a greater mean arterial pressure (MAP) than did Dex70. FCD was substantially higher for MetRBC [82 (SD 6) of baseline] versus Dex70 [38 (SD 10) of baseline], and reduction of methemoglobin to oxy...Continue Reading

References

Sep 1, 1975·Microvascular Research·M IntagliettaW R Tompkins
May 1, 1992·The American Journal of Physiology·A L Loeb, D E Longnecker
Mar 1, 1989·The American Journal of Physiology·R Y ChenS Chien
Jun 1, 1986·The American Journal of Physiology·H H Lipowsky, J C Firrell
Jun 1, 1985·Circulation Research·J LindenfeldL D Horwitz
May 1, 1973·Microvascular Research·M Intaglietta, W R Tompkins
Feb 1, 1966·The American Journal of Physiology·J E Smith, E Beutler
Apr 1, 1984·The American Journal of Physiology·A ColantuoniM Intaglietta
Jan 1, 1980·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·B EndrichK Messmer
Jul 1, 1995·Anesthesia and Analgesia·D N DossP A Murray
Jan 26, 1993·Biochemical Pharmacology·B MayerK Schmidt
Sep 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K F WaschkeW Kuschinsky
Oct 1, 1993·The American Journal of Physiology·I P Torres Filho, M Intaglietta
Jan 1, 1993·The American Journal of Physiology·M J Kuchan, J A Frangos
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·A G TsaiM Intaglietta
Dec 9, 1998·The American Journal of Physiology·A G TsaiM Intaglietta
Sep 10, 1999·BMJ : British Medical Journal·D G Altman, J M Bland
Jan 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·T OsanaiK Okumura
Dec 12, 2001·Acta Anaesthesiologica Scandinavica·O V EvgenovL J Bjertnaes
Jun 14, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Amy G TsaiRobert M Winslow
Jun 14, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Amy G TsaiMarcos Intaglietta
Jul 5, 2003·Physiological Reviews·Amy G TsaiMarcos Intaglietta
Jul 8, 2003·American Journal of Therapeutics·Jack Clifton, Jerrold B Leikin
Feb 21, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Pedro CabralesMarcos Intaglietta
Mar 27, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Qining QinJames M Downey
Jun 12, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Pedro CabralesMarcos Intaglietta
Aug 7, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Pedro CabralesMarcos Intaglietta
Dec 4, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Amy G TsaiMarcos Intaglietta
Jul 12, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Judith MartiniMarcos Intaglietta
Oct 11, 2005·Free Radical Biology & Medicine·Pedro CabralesMarcos Intaglietta

❮ Previous
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Citations

Jun 1, 2010·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Albert K Y TsuiGregory M T Hare
Aug 8, 2009·Antioxidants & Redox Signaling·Paul W Buehler, Felice D'Agnillo
Mar 26, 2011·Seminars in Dialysis·Dominic TrainorAndrew Ferguson
Aug 22, 2007·American Journal of Respiratory Cell and Molecular Biology·Beatriz Y Salazar VázquezMarcos Intaglietta
Jan 22, 2011·Bioanalysis·Ruth E SimoniFrancisco R Aquino Neto
Apr 25, 2013·Annales Françaises D'anesthèsie Et De Rèanimation·N MorelG Janvier
Jan 29, 2013·Best Practice & Research. Clinical Anaesthesiology·Daniel De Backer, Diego Orbegozo Cortés
Apr 22, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Surapong ChatpunPairaya Rujirojindakul
Jul 22, 2010·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Amy G TsaiMarcos Intaglietta
May 19, 2009·Critical Care Medicine·Aryeh Shander, Lawrence Tim Goodnough
Jul 27, 2007·Best Practice & Research. Clinical Anaesthesiology·Caveh Madjdpour, Donat R Spahn
Jul 27, 2007·Best Practice & Research. Clinical Anaesthesiology·Emre Almac, Can Ince
Nov 10, 2006·Resuscitation·Pedro CabralesMarcos Intaglietta
Sep 21, 2011·Paediatric Anaesthesia·Gianluca BertolizioAndre Obenaus
Sep 18, 2012·Journal of Cardiac Surgery·Giuseppe CrescenziMarco Rossi
Jun 3, 2015·The Veterinary Clinics of North America. Small Animal Practice·Stuart Bliss
Aug 5, 2014·BioMed Research International·Jan BilskiJakub Marchewka
Oct 29, 2013·Journal of Cardiothoracic and Vascular Anesthesia·Nick J KoningChrista Boer
Nov 7, 2016·Anesthesiology Clinics·Aryeh ShanderMazyar Javidroozi
Jul 22, 2016·British Journal of Anaesthesia·S ScollettaM Ranucci
Nov 29, 2016·Antioxidants & Redox Signaling·Viktoria KuhnMiriam M Cortese-Krott
Jan 26, 2017·Plastic and Reconstructive Surgery·Koji KanayamaKotaro Yoshimura
Dec 15, 2015·Seminars in Cardiothoracic and Vascular Anesthesia·Gregg P LobelAryeh Shander
Mar 20, 2018·Current Opinion in Critical Care·Arnaldo DubinGlenn Hernández
May 30, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Pedro Cabrales, Amy G Tsai
Apr 25, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Albert K Y TsuiGregory M T Hare
Mar 19, 2016·Journal of Applied Physiology·Gonzalo FerraraArnaldo Dubin
Jan 6, 2016·Critical Care : the Official Journal of the Critical Care Forum·Can Ince
Mar 29, 2019·Critical Care : the Official Journal of the Critical Care Forum·Donat R SpahnRolf Rossaint

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