Blood/gas equilibrium of carbon dioxide in lungs. A critical review

Respiration Physiology
P Scheid, J Piiper

Abstract

(1) The scope of this review is to examine the experimental evidence for the existence of negative PCO2 differences between pulmonary capillary blood and lung gas, [delta PCO2(b-G)], which have been observed both during rebreathing, when CO2 was at equilibrium, and during steady state gas exchange, particularly in hypercapnia. (2) The mechanism that have been invoked to explain negative delta PCO2(b-G) include (i) slow equilibration of the system CO2/HCO3-/H+ in blood, and (ii) effects of a negatvely charged surface of the pulmonary capillary endothelium. While the first postulated mechanism appears to be quantitatively insufficient to explain the results, the second seems to lead to serious qualitative difficulties. (3) Existence of negative delta PCO2(b-G) in CO2 equilibrium would invalidate the basis of the conventional analysis of alveolar gas exchange. (4) A critical analysis of the experimental evidence for the existence of negative delta PCO2(b-G) is presented. It includes the identification of directional experimental errors leading to spurious negative delta PCO2(b-G), and a critical review of the literature data in this regard. (5) Results of own experiments, conducted in an attempt to consider all possible sources of...Continue Reading

References

Sep 1, 1978·The Journal of Clinical Investigation·E D Crandall, J E O'Brasky
Mar 1, 1978·Respiration Physiology·R G BoutilierD P Toews
Jan 1, 1976·Annual Review of Physiology·R E Forster, E D Crandall
Mar 1, 1975·Respiration Physiology·J Piiper, P Scheid
May 30, 1975·Pneumonologie. Pneumonology·H Slama, P Scheid
Jan 1, 1974·Respiration; International Review of Thoracic Diseases·W LieseG Cumming
Jan 1, 1971·Annual Review of Physiology·J Piiper, P Scheid
Dec 1, 1971·Respiration Physiology·S GodfreyE Wolf
Dec 1, 1968·Respiration Physiology·H D Van LiewA J Olszowka
Aug 1, 1969·Respiration Physiology·G H GurtnerL E Farhi
Feb 1, 1960·Proceedings of the Society for Experimental Biology and Medicine·S M CAIN, A B OTIS
Jan 1, 1963·Acta Psychiatrica Scandinavica. Supplementum·P O BARR

Citations

Jan 1, 1990·European Journal of Applied Physiology and Occupational Physiology·U HoffmannJ Stegemann
Mar 1, 1982·Pflügers Archiv : European journal of physiology·F HayashiY Honda
Jun 1, 1986·Pflügers Archiv : European journal of physiology·W F Yee, E M Scarpelli
Jan 1, 1984·International Journal of Clinical Monitoring and Computing·J S GravensteinD A Paulus
Jul 21, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M LaffonC Mercier
Oct 1, 1980·Respiration Physiology·J B West, P D Wagner
Feb 1, 1983·Respiration Physiology·J A LoeppkyE R Fletcher
Feb 1, 1986·Respiration Physiology·P E BicklerF L Powell
Aug 1, 1988·Respiration Physiology·W E Fordyce, R K Kanter
Jan 1, 1982·Comparative Biochemistry and Physiology. A, Comparative Physiology·S Long
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·G F RaffertyJ Moxham
Jan 1, 1992·The American Review of Respiratory Disease·J S ClarkD Y Sue
Jan 1, 1993·The American Review of Respiratory Disease·P M SimonJames B Skatrud
May 30, 2003·American Journal of Respiratory and Critical Care Medicine·Tarek SharsharFrédéric Lofaso
Apr 26, 2003·American Journal of Respiratory and Critical Care Medicine·Anthony J RiceJerome A Dempsey
Mar 1, 1989·Respiration Physiology·K YamaguchiJ Piiper
Apr 6, 2011·Pediatric Pulmonology·Emmanuel LopezGuy Moriette
May 1, 1983·Clinical Allergy·J C Delaney
Apr 12, 2016·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Robert L Cieri, C G Farmer
Jul 3, 2015·Physiology·C G Farmer

Related Concepts

Metazoa
Aves
Blood Capillaries
Carbon Dioxide
Plasma Membrane
Canis familiaris
Hypercapnia
Lung
Dioxygen
Respiration

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