Bloodstream infection in adults with sickle cell disease: association with venous catheters, Staphylococcus aureus, and bone-joint infections

Medicine
Virginie ZarroukPhilippe Lesprit

Abstract

Although well documented in children with sickle cell disease (SCD), the incidence, cause, and outcome of bloodstream infection (BSI) are poorly defined in adults with SCD. Through a 5-year retrospective analysis of a cohort of 900 patients followed at our institution, we identified 56 episodes of BSI in 47 patients. The incidence rate of BSI was 1.2 episodes per 100 patient-years. As compared to the patients followed in the cohort, those with BSI were more likely to be younger (p = 0.001), to have Hb-S disease (p = 0.008), severe disease (p = 0.001), or additional immunosuppression (p = 0.05). BSI was hospital-acquired in 46% of cases and mainly associated with venous catheters (41%) and Staphylococcus aureus (34%). Pneumococci were rarely identified (10.7%). Despite an adequate duration of antibiotic therapy, the course of BSI was marked by a high frequency of associated bone-joint infection. Bone-joint infection was noted in 18 patients (32% of episodes) and occurred either during the initial BSI episode (13 patients) or 1-6 months after BSI resolution (5 patients). Factors associated with the occurrence of bone-joint infection were previous osteonecrosis (relative risk, 2.5; 95% confidence interval, 1.2-5.3) and S. aureus i...Continue Reading

References

Jan 28, 1978·Lancet·J L SullivanR J Wedgwood
Aug 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B GodeauF Galacteros
Jun 1, 1988·American Journal of Infection Control·J S GarnerJ M Hughes
Jun 19, 1986·The New England Journal of Medicine·M H GastonJ S Lobel
Nov 1, 1988·American Journal of Hematology·G PhillipsO Akwari
Oct 1, 1986·The Journal of Pediatrics·H S ZarkowskyD Wethers
Jun 9, 1994·The New England Journal of Medicine·O S PlattP P Klug
Jun 1, 1996·Clinical and Laboratory Haematology·C E McCreadyT C Pearson
May 20, 1999·Archives of Disease in Childhood·S A MagnusG R Serjeant
Feb 9, 2002·American Journal of Hematology·Michael R JengElliott Vichinsky
Apr 18, 2002·The Hematology Journal : the Official Journal of the European Haematology Association·Véronique PerronneBertrand Godeau
Sep 10, 2002·Journal of Pediatric Hematology/oncology·Jeffrey HordKim Smith-Whitley
Feb 21, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B H Y ChungY L Lau
Mar 15, 2003·The Journal of Bone and Joint Surgery. American Volume·P HernigouF Galacteros
Apr 18, 2003·The New England Journal of Medicine·Greg S MartinMarc Moss
May 22, 2003·Journal of Pediatric Hematology/oncology·Cynthia F NorrisKarin L McGowan
Apr 6, 2004·Journal of Vascular and Interventional Radiology : JVIR·Steven C WagnerKevin L Sullivan

❮ Previous
Next ❯

Citations

Aug 29, 2009·La Revue de médecine interne·F LionnetUNKNOWN groupe de recommandations et d'étude de la drépanocytose de l'adulte (GREDA)
Jul 24, 2014·The New England Journal of Medicine·Lorry G Rubin, William Schaffner
Aug 24, 2007·The Journal of Infection·François LionnetJacques Cadranel
May 7, 2015·British Journal of Haematology·Valentine BrousseMariane de Montalembert
May 29, 2015·British Journal of Haematology·Amy SobotaMartin Steinberg
May 27, 2015·La Revue de médecine interne·A HabibiUNKNOWN centre de référence maladies rares « syndromes drépanocytaires majeurs »
Mar 11, 2017·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Matthew S KarafinJoshua J Field
Nov 12, 2015·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·Kiyoharu MuranakaNaoto Hosokawa
May 29, 2019·The American Journal of Nursing·Paula TanabeMary Hulihan
Apr 18, 2021·Annals of Hematology·Jaffar A Al-TawfiqMohammed H AlEdreesi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

© 2021 Meta ULC. All rights reserved