Bloodstream infections in oncology patients at Red Cross War Memorial Children's Hospital, Cape Town, from 2012 to 2014

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Tisungane MvaloAlan Davidson

Abstract

This study was performed to investigate the epidemiology of bloodstream infection (BSI) in oncology patients at Red Cross War Memorial Children's Hospital (RCWMCH), Cape Town, with focus placed on the most common causes, complications, and antimicrobial susceptibilities in BSI. A retrospective cross-sectional study was conducted in the Haematology-Oncology Unit of RCWMCH. All positive blood cultures from RCWMCH oncology patients obtained in 2012 to 2014 were retrieved to identify cases of BSI. Three hundred and forty-three positive cultures were identified, for 150 BSI episodes among 89 patients; 49.1% of the culture isolates were Gram-positive bacteria, 41.6% were Gram-negative bacteria, and 9.3% were fungal. Coagulase-negative Staphylococcus and viridans group Streptococcus were the most common Gram-positive isolates. Escherichia coli and Klebsiella species were the most common Gram-negative isolates. The majority of BSI episodes occurred in patients with haematological malignancies (74%), in the presence of severe neutropenia (76.4%), and were associated with chemotherapy (88%). Complications occurred in 14% of BSI. Fungal infections had the highest prevalence of complications (21.4%). Three children died during BSI, giving ...Continue Reading

Citations

Feb 12, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Jonathan AsanteSabiha Y Essack
May 27, 2020·The Pediatric Infectious Disease Journal·Gita NaiduShabir Ahmed Madhi
Aug 1, 2019·BMC Research Notes·Margaret LubwamaFreddie Bwanga
Mar 16, 2021·Pediatric Blood & Cancer·Glenn Mbah AfungchwiPeter B Hesseling

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