Blue-dye intraoperative sentinel lymph node mapping in early non-small cell lung cancer

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Witold RzymanJ Skokowski

Abstract

The blue-dye staining method of sentinel lymph node identification in lung cancer patients has been scarcely reported. The study was designed to assess the sensitivity, accuracy and negative predictive value (NPV) of intraoperative sentinel lymph node mapping in patients with non-small cell lung cancer by means of staining with colloid or water solution of blue dye. One hundred and ten patients with clinically confirmed NO non-small cell lung cancer were enrolled into prospective study of intraoperative sentinel node identification. Four quadrants of the peritumoral tissue were injected with 4 ml of blue dye. After complete lymphadenectomy, all resected lymph nodes were examined with conventional hematoxylin-eosine staining. All negative sentinel nodes were searched for metastatic deposits with both serial sections and immunohistochemistry for cytokeratines. The blue-dye technique was characterized by unacceptably low sentinel node identification rate (IR) and low sensitivity (27% and 67% respectively). No significant differences were found in either the sensitivity or NPV among the colloid or water solutions of the blue dye applied. Although patent blue (colloid) was superior to water solution of methylene blue in identifying ...Continue Reading

References

Sep 1, 1994·Annals of Surgery·A E GiulianoD L Morton
Jun 1, 1997·Chest·C F Mountain, C M Dresler
Oct 1, 1998·The New England Journal of Medicine·D KragP Beitsch
Jan 27, 1999·The Journal of Thoracic and Cardiovascular Surgery·A G LittleK D Murray
Sep 2, 2000·The Annals of Thoracic Surgery·M J LiptayW A Fry
Nov 27, 2001·American Journal of Surgery·L Tafra
Dec 12, 2001·The British Journal of Surgery·L BergkvistM Thörn
Mar 14, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Steven M Keller
Apr 17, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael J LiptayWilliam Watkin
Sep 20, 2002·The Annals of Thoracic Surgery·Frank E SchmidtMark H Rozans
Feb 1, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Franca M A MelfiCarlo Alberto Angeletti
May 20, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·D LardinoisW Weder
Dec 29, 2004·The Annals of Thoracic Surgery·Edward G SolteszTomislav Mihaljevic

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Citations

Nov 24, 2011·Annals of Surgical Oncology·Mark B Faries, Donald L Morton
Jul 22, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kosuke KashiwabaraHirotsugu Kohrogi
Aug 13, 2013·Thoracic Surgery Clinics·Shinichiro Miyoshi
Aug 28, 2007·The Annals of Thoracic Surgery·Bryan A WhitsonMichael A Maddaus
Apr 17, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H M KocherA G Patel
Nov 6, 2013·Biotechnology Advances·Aidan CousinsBenjamin Thierry
Dec 21, 2014·Seminars in Thoracic and Cardiovascular Surgery·Krista J Hachey, Yolonda L Colson
Apr 27, 2016·Thoracic Surgery Clinics·Christopher S DigesuYolonda L Colson
Jul 17, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nathan Andrew RohnerSusan Napier Thomas
Jul 15, 2020·General Thoracic and Cardiovascular Surgery·Alexander GregorKazuhiro Yasufuku
Dec 14, 2011·Biomedical Optics Express·Metasebya SolomonJoseph P Culver
Aug 17, 2020·Microscopy Research and Technique·Sadia MalikHafeez Ullah

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