Blue light irradiation triggers the antimicrobial potential of ZnO nanoparticles on drug-resistant Acinetobacter baumannii

Journal of Photochemistry and Photobiology. B, Biology
Ming-Yeh YangAnren Hu

Abstract

Photodynamic inactivation (PDI) is a non-invasive and safe therapeutic method for microbial infections. Bacterial antibiotic resistance is caused by antibiotics abuse. Drug-resistant Acinetobacter spp. is a serious problem in hospitals around the world. These pathogens from nosocomial infections have high mortality rates in frailer people, and Acinetobacter spp. is commonly found in immunocompromised patients. Visible light is safer than ultraviolet light (UV) for PDI of nosocomial pathogens with mammalian cells. Zinc oxide nanoparticles (ZnO-NPs) were used in this study as an antimicrobial agent and a photosensitizer. ZnO is recognized as safe and has extensive usage in food additives, medical and cosmetic products. In this study, we used 0.125 mg/ml ZnO-NPs combined with 10.8 J/cm2blue light (BL) on Acinetobacter baumannii (A. baumannii) that could significantly reduce microbial survival. However, individual exposure to ZnO-NPs does not affect the viability of A. baumannii. BL irradiation could trigger the antimicrobial ability of ZnO nanoparticles on A. baumannii. The mechanism of photocatalytic ZnO-NPs treatment for sterilization occurs through bacterial membrane disruptions. Otherwise, the photocatalytic ZnO-NPs treatment ...Continue Reading

Citations

Jun 27, 2019·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Lea K Davis, Barbara E Stranger
Aug 20, 2019·Open Forum Infectious Diseases·Zekun LiQiwen Yang
Jun 27, 2019·Advanced Healthcare Materials·Qingyan JiaWei Huang
Aug 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Padmanaban SivakumarMin Suk Shim
Apr 17, 2019·Frontiers in Microbiology·Mansura S MulaniKarishma R Pardesi
Jul 6, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Meei-Ju YangJi-Yuan Liang
Oct 21, 2020·Nanoscale·Alina BekmukhametovaAntonio Lauto
Oct 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Giftson J SenapathyHeidi Abrahamse

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