Blue light versus red light for photodynamic therapy of basal cell carcinoma in patients with Gorlin syndrome: A bilaterally controlled comparison study

Photodiagnosis and Photodynamic Therapy
Edward V MaytinBo Hu

Abstract

Photodynamic therapy (PDT) is a non-scarring alternative for treating basal cell carcinoma (BCC) in patients with Basal Cell Nevus Syndrome (BCNS), also known as Gorlin syndrome. In Europe, red light (635 nm) is the predominant source for PDT, whereas in the United States blue light (400 nm) is more widely available. The objective of this study was to conduct a head-to-head comparison of blue light and red light PDT in the same BCNS patients. In a pilot study of three patients with 141 BCC lesions, 5-aminolevulinate (20% solution) was applied to all tumors. After 4 h, half of the tumors were illuminated with blue light and the remainder with red light. To ensure safety while treating this many tumors simultaneously, light doses were escalated gradually. Six treatments were administered in three biweekly sessions over 4 months, with a final evaluation at 6 months. Tumor status was documented with high-resolution photographs. Persistent lesions were biopsied at 6 months. Clearance rates after blue light (98%) were slightly better than after red light (93%), with blue light shown to be statistically non-inferior to red light. Eight suspicious lesions were biopsied, 5 after red light (5/5 were BCC) and 3 after blue light (1 was BCC...Continue Reading

Citations

Feb 23, 2020·Photochemistry and Photobiology·Edward V Maytin, Tayyaba Hasan
Jun 4, 2018·Dermatology and Therapy·Barbara J CohenPhilip R Cohen
Jan 24, 2020·International Journal of Molecular Sciences·Brandon LeviskasTroy Skwor
Sep 3, 2019·Current Dermatology Reports·Alisen HuangJared Jagdeo
Oct 30, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Lijuan LiZhigang Xie
Nov 22, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nicholas J Collier, Lesley E Rhodes
Mar 1, 2021·Journal of the American Academy of Dermatology·Evan AustinJared Jagdeo
Dec 4, 2020·Journal of Photochemistry and Photobiology. B, Biology·María Laura MugasAdriana Casas
Nov 4, 2020·Biomacromolecules·Heinz Fabian RaberFrank Rosenau
Jul 31, 2021·ACS Applied Bio Materials·Paige J LeValleyApril M Kloxin
Nov 18, 2021·Journal of Applied Microbiology·Shae D MorganThomas Roussel
Dec 12, 2021·Scientific Reports·María Laura MugasAdriana Casas

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