Blue Te Nanoneedles with Strong NIR Photothermal and Laser-Enhanced Anticancer Effects as "All-in-One" Nanoagents for Synergistic Thermo-Chemotherapy of Tumors

Advanced Healthcare Materials
Nuo YuZhigang Chen

Abstract

The conventional blue Te nanostructures exhibit strong photoabsorption in the near-infrared (NIR) region but have ultralong lengths (tenths of micrometers), while purple Te nanostructures with short lengths (such as nanodots and nanorods) show extremely low intensity of the NIR band. These Te nanostructures cannot achieve simultaneously both the suitable size and high NIR absorption, undoubtedly hindering their bioapplication. Herein, blue Te nanoneedles are prepared through a facile one-pot reduction route for the first time, and they have strong NIR absorbance while maintaining the shortened length (<500 nm). Compared to purple Te nanorods, blue Te nanoneedles have higher photothermal conversion efficiency using a 915 nm laser and exhibit laser-enhanced antioxidative activity toward scavenging of free radicals. These blue nanoneedles show significant discrimination in cytotoxicity toward different cell-lines, and demonstrate anticancer activity induced by mitochondrial dysfunction. Furthermore, when blue Te nanoneedles are injected in tumors of mice, tumors can be detected by thermal/photoacoustic imaging, and satisfactory therapeutic effects are achieved through the synergistic thermo-chemotherapy in contrast to the limited ...Continue Reading

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Citations

May 21, 2019·Chemical Society Reviews·Xiaofeng ChenHuanghao Yang
Sep 18, 2020·Chemical Communications : Chem Comm·Yasun JingWenliang Li
Oct 13, 2020·Frontiers in Bioengineering and Biotechnology·Leilei ZhangXiaolin Huang
Dec 29, 2020·International Journal of Nanomedicine·Jinghua SunRuiping Zhang
Jul 16, 2021·National Science Review·Xiang LingQianjun He
Aug 21, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Weijian ChenXiaopeng Ma

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