Blueberry consumption prevents loss of collagen in bone matrix and inhibits senescence pathways in osteoblastic cells.

Age
Jian ZhangJin-Ran Chen

Abstract

Ovariectomy (OVX)-induced bone loss has been linked to increased bone turnover and higher bone matrix collagen degradation as the result of osteoclast activation. However, the role of degraded collagen matrix in the fate of resident bone-forming cells is unclear. In this report, we show that OVX-induced bone loss is associated with profound decreases in collagen 1 and Sirt1. This was accompanied by increases in expression and activity of the senescence marker collagenase and expression of p16/p21 in bone. Feeding a diet supplemented with blueberries (BB) to pre-pubertal rats throughout development or only prior to puberty [postnatal day 21 (PND21) to PND34] prevents OVX-induced effects on expression of these molecules at PND68. In order to provide more evidence and gain a better understanding on the association between bone collagen matrix and resident bone cell fate, in vitro studies on the cellular senescence pathway using primary calvarial cells and three cell lines (ST2 cells, OB6, and MLO-Y4) were conducted. We found that senescence was inhibited by collagen in a dose-response manner. Treatment of cells with serum from OVX rats accelerated osteoblastic cell senescence pathways, but serum from BB-fed OVX rats had no effect....Continue Reading

References

Apr 17, 1979·Calcified Tissue International·J C WallJ W Jeffery
May 31, 1990·Nature·C B HarleyC W Greider
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·G P DimriO Pereira-Smith
Aug 5, 1999·Experimental Gerontology·A J Bailey, L Knott
Jun 7, 2002·Endocrine Reviews·B Lawrence RiggsL Joseph Melton
Apr 8, 2004·Developmental Cell·Rowena McBeathChristopher S Chen
May 5, 2004·Journal of Biomedicine & Biotechnology·Roman M. SalasznykGeorge E. Plopper
Jun 4, 2004·Nature·Frédéric PicardLeonard Guarente
Jun 11, 2004·Annual Review of Biochemistry·Agata Smogorzewska, Titia de Lange
Aug 23, 2006·Cell·Adam J EnglerDennis E Discher
Aug 26, 2006·Nature Clinical Practice. Rheumatology·Clifford J Rosen, Mary L Bouxsein
Sep 15, 2006·The Journal of Pharmacology and Experimental Therapeutics·Jin-Ran ChenMartin J J Ronis
Aug 2, 2007·Nature Reviews. Molecular Cell Biology·Judith Campisi, Fabrizio d'Adda di Fagagna
Aug 30, 2008·Cell·Valery KrizhanovskyScott W Lowe
Oct 14, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jin-Ran ChenMartin J Ronis
Aug 6, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kirsten EcklundCatherine M Gordon
Sep 15, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Ritsuko Nakano-KurimotoHiroaki Matsubara
Mar 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kristopher A KilianMilan Mrksich
May 26, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jin-Ran ChenMartin J J Ronis
May 17, 2011·Free Radical Biology & Medicine·Yi HuQingsong Liu
Sep 10, 2011·Science·Benjamin L ProsserW J Lederer

❮ Previous
Next ❯

Citations

Jul 2, 2014·Current Osteoporosis Reports·Archana KamalakarLarry J Suva
Jul 28, 2018·The Journal of Endocrinology·Jin Ran ChenKartik Shankar
Apr 22, 2019·FEBS Open Bio·Vladana DomazetovicMaria Teresa Vincenzini
Apr 11, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jian ZhangJin-Ran Chen
Jan 12, 2017·International Journal of Molecular Medicine·Akari MinamiSatoru Matsuda
Oct 14, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jin-Ran ChenKartik Shankar
Oct 18, 2016·Current Opinion in Clinical Nutrition and Metabolic Care·Marie-Jeanne DaviccoVéronique Coxam
Oct 12, 2018·The Journal of Endocrinology·Jin-Ran ChenKartik Shankar
Dec 15, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Amy Y SatoTeresita Bellido
Jan 17, 2021·Life Sciences·Ye ChenEn Luo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.