PMID: 16627932Apr 22, 2006Paper

Blueberry extract alters oxidative stress-mediated signaling in COS-7 cells transfected with selectively vulnerable muscarinic receptor subtypes

Journal of Alzheimer's Disease : JAD
J A JosephD Bielinski

Abstract

Previous research has indicated that selective vulnerability to oxidative stress may be important in determining regional differences in functional declines in neuronal aging. Oxidative stress vulnerability may involve selective deficits in Ca2+ buffering (Ca2+ recovery time following oxotremorine application) to oxidative stress, determined in-part by receptor subtype with M1, M2 and M4 AChR showing greater oxidative stress-induced loss [via dopamine (DA) exposure for 4 hrs] of Ca2+ recovery time than that seen in M3 or M5 cells. Deficits were antagonized by pre-treating M1, M2, or M4 AChR-transfected cells with blueberry (BB) extract. Thus, we assessed whether these differences in oxidative stress vulnerability might involve differential patterns of DA-induced protein kinase (PKCalpha, PKCgamma) and/or cyclic AMP response element binding protein (CREB) activation, and whether these differences might be altered by BB treatment. M1 or M3 AChR-transfected COS-7 cells were exposed to 1 mM DA, and activation of phospho-(p) mitogen-activated protein kinase (MAPK) signaling was examined by immunoblotting analyses. The results showed that DA increased pCREB and pPKCgamma for both M1- and M3-transfected cells, and BBs decreased these ...Continue Reading

Citations

Sep 7, 2018·Frontiers in Cellular Neuroscience·Md Ezazul HaqueDong-Kug Choi
May 22, 2013·Oxidative Medicine and Cellular Longevity·Denise McCormack, David McFadden
Feb 9, 2017·Cognitive Neurodynamics·Bhagyashree NaikAnuradha Majumdar
Oct 29, 2008·Journal of Agricultural and Food Chemistry·James A JosephBarbara Shukitt-Hale
Nov 19, 2021·Advances in Nutrition·Laura Felgus-LavefveJamie I Baum

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