Bluish-gray fingernail discoloration due to the use of nivolumab.

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners
Miguel Michel OcampoConstantin A Dasanu

Abstract

Immune checkpoint inhibitors have improved clinical outcomes in a wide range of cancers. While skin toxicity is not uncommon with immune checkpoint inhibitors, generalized nail discoloration has not been reported with their use in oncology. Herein, we report a unique case of bluish-gray fingernail discoloration due to nivolumab therapy for relapsed melanoma.Management and outcome: This condition reversed completely 10 weeks after nivolumab discontinuation. Naranjo nomogram assessment renders the causality relationship between nivolumab and nail discoloration probable. To our knowledge, this is the first case report of an unusual bluish-gray nail discoloration due to therapy with nivolumab. The mechanism by which nivolumab causes this side effect remains to be elucidated.

References

Aug 1, 1981·Clinical Pharmacology and Therapeutics·C A NaranjoD J Greenblatt
Apr 10, 2013·Annales de dermatologie et de vénéréologie·V Sibaud, C Robert
Jul 20, 2014·Seminars in Cutaneous Medicine and Surgery·Jennifer Nam Choi
Jan 17, 2015·Journal of the American Academy of Dermatology·James B MacdonaldAleksandar Sekulic
Sep 5, 2015·Current Treatment Options in Oncology·Silvina B PuglieseBernice Y Kwong
Nov 9, 2016·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Constantin A DasanuSteven C Plaxe
Jan 10, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey S WeberCaroline Robert

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Citations

Jul 25, 2021·Journal of Clinical Medicine·Lorenza BurziSimone Ribero

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Methods Mentioned

BETA
biopsy

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