Blunted adenosine A2a receptor function in platelets in patients with major depression

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Michael BerkB Jersky

Abstract

There is provisional evidence of involvement of adenosine in depression. In this study, the second messenger intracellular calcium response in platelets was measured in patients with major depression and controls using spectrofluorometry. The primary result of this study was a statistically significantly blunted second messenger response to agonist stimulation in the depressed group compared to the control group at the 50 and 100 nM and 1 microM dosage levels. This suggests that dysregulation of the adenosine A2a receptor may be present in depression.

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Citations

May 1, 2001·Yeast·C CompagnoD Porro
Apr 12, 2014·BMC Psychiatry·Jerome SarrisMichael Berk
Nov 27, 2009·Sleep Medicine Reviews·Luc Staner
Feb 22, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kelly R LobatoAna Lúcia S Rodrigues
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Nov 7, 2019·International Journal of Molecular Sciences·Nina Wolska, Marcin Rozalski
Dec 8, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Joana I GomesSandra H Vaz
Jun 4, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·P V Pchelina, M G Poluektov

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