Blunted autonomic response in cluster headache patients

Cephalalgia : an International Journal of Headache
Mads BarloeseRigmor Jensen

Abstract

Cluster headache (CH) is a disabling headache disorder with chronobiological features. The posterior hypothalamus is involved in CH pathophysiology and is a hub for autonomic control. We studied autonomic response to the head-up tilt table test (HUT) including heart rate variability (HRV) in CH patients and compared results to healthy controls. Twenty-seven episodic and chronic CH patients and an equal number of age-, sex- and BMI-matched controls were included. We analyzed responses to HUT in the time and frequency domain and by non-linear analysis. CH patients have normal cardiovascular responses compared to controls but increased blood pressure. In the frequency analysis CH patients had a smaller change in the normalized low- (LF) (2.89 vs. 13.38, p < 0.05) and high-frequency (HF) (-2.86 vs. -13.38, p < 0.05) components as well as the LF/HF ratio (0.81 vs. 2.62, p < 0.05) in response to tilt. In the Poincaré plot, the change in ratio between long- and short-term variation was lower in patients (SD1/SD2, -0.05 vs. -0.17, p < 0.05). CH patients show decreased autonomic response to HUT compared to healthy controls. This can be interpreted as dysregulation in the posterior hypothalamus and supports a theory of central autonomic ...Continue Reading

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Citations

Mar 30, 2016·Current Neurology and Neuroscience Reports·Jessica Ailani
Jun 19, 2015·Headache·Mads C J BarloeseRigmor H Jensen
Aug 21, 2015·The Journal of Headache and Pain·Mads Christian Johannes Barloese
Sep 25, 2017·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Mads C J Barloese
Nov 7, 2017·Clinical Physiology and Functional Imaging·Mads BarloeseRigmor H Jensen
May 31, 2019·Headache·Ilse F de CooRolf Fronczek

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