Blunted Maximal and Submaximal Responses to Cardiopulmonary Exercise Tests in Patients With Parkinson Disease

Archives of Physical Medicine and Rehabilitation
Hélcio KanegusukuC L Forjaz

Abstract

To investigate submaximal and maximal responses during maximal cardiopulmonary exercise tests in subjects with Parkinson disease (PD). Cross-sectional. A PD association. A sample (N=68) of subjects with PD (n=48; mean age, 66±8y; modified Hoehn and Yahr stage between 2 and 3; "on" state of medication) and age-matched controls without PD (n=20; mean age, 64±9y). Maximal cardiopulmonary exercise test on a cycle ergometer. Oxygen uptake (V˙o2), systolic blood pressure (SBP), and heart rate assessed at rest, submaximal intensities (ie, anaerobic threshold [AT] and respiratory compensation point), and maximal intensity (peak exercise). Compared with control subjects, subjects with PD had lower V˙o2, heart rate, and SBP at respiratory compensation point and peak exercise (V˙o2: 14.6±3.6mL⋅kg⋅min vs 17.9±5.5mL⋅kg⋅min and 17.7±4.8mL⋅kg⋅min vs 21.5±6.6mL⋅kg⋅min; heart rate: 119±17beats/min vs 139±12beats/min and 132±20beats/min vs 158±13beats/min; SBP: 151±17mmHg vs 172±20mmHg and 166±21mmHg vs 187±24mmHg; P≤.05). They also had lower heart rate at AT (102±14beats/min vs 110±13beats/min; P≤.05), whereas V˙o2 and SBP at this intensity were similar to those of control subjects. Subjects with PD demonstrated blunted metabolic and cardiovasc...Continue Reading

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Citations

Jul 29, 2017·Clinical Physiology and Functional Imaging·Rafael Yokoyama FecchioCláudia Lúcia de Moraes Forjaz
Jun 28, 2018·Journal of Neurophysiology·Jeann L Sabino-CarvalhoLauro C Vianna
May 13, 2018·PM & R : the Journal of Injury, Function, and Rehabilitation·Roberto S MiyasatoHélcio Kanegusuku
Dec 7, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Kirk B RobersonAndrew N L Buskard
Nov 9, 2018·Frontiers in Aging Neuroscience·Simon SteibKlaus Pfeifer
Jan 17, 2021·Archives of Physical Medicine and Rehabilitation·Amanda L PenkoJay L Alberts
Jan 21, 2021·Journal of Functional Morphology and Kinesiology·Andrew E PechsteinAndrew A Guccione
Apr 6, 2021·Frontiers in Physiology·Jeann L Sabino-CarvalhoLauro C Vianna
May 11, 2021·Neurology·Guillaume Lamotte, Eduardo E Benarroch
Aug 12, 2021·International Journal of Sports Medicine·Hélcio KanegusukuRaphael Mendes Ritti-Dias

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