Blunted neuronal calcium response to hypoxia in naked mole-rat hippocampus.

PloS One
Bethany L PetersonChristopher P Fall

Abstract

Naked mole-rats are highly social and strictly subterranean rodents that live in large communal colonies in sealed and chronically oxygen-depleted burrows. Brain slices from naked mole-rats show extreme tolerance to hypoxia compared to slices from other mammals, as indicated by maintenance of synaptic transmission under more hypoxic conditions and three fold longer latency to anoxic depolarization. A key factor in determining whether or not the cellular response to hypoxia is reversible or leads to cell death may be the elevation of intracellular calcium concentration. In the present study, we used fluorescent imaging techniques to measure relative intracellular calcium changes in CA1 pyramidal cells of hippocampal slices during hypoxia. We found that calcium accumulation during hypoxia was significantly and substantially attenuated in slices from naked mole-rats compared to slices from laboratory mice. This was the case for both neonatal (postnatal day 6) and older (postnatal day 20) age groups. Furthermore, while both species demonstrated more calcium accumulation at older ages, the older naked mole-rats showed a smaller calcium accumulation response than even the younger mice. A blunted intracellular calcium response to hypo...Continue Reading

References

Nov 20, 1978·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·M W Smith, L G Jarvis
Mar 23, 1978·Nature·A W CromptonJ A Jagger
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·K S LeeG Lynch
Sep 1, 1989·Brain Research. Developmental Brain Research·D MullerG Lynch
Feb 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J K DeshpandeT Wieloch
Sep 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P E BicklerB M Hansen
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·P W HochachkaS C Land
Feb 20, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K U Frerichs, J M Hallenbeck
Jun 16, 1999·Experimental Brain Research·R Metherate, S J Cruikshank
Oct 3, 1999·Physiological Reviews·A TakahashiB Herman
Oct 3, 1999·Physiological Reviews·P Lipton
Nov 24, 2001·Respiration Physiology·M Erecińska, I A Silver
Jan 31, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Matthew H RoutleyGillian M C Renshaw
Aug 10, 2004·The Journal of Experimental Biology·K L DrewY L Ma
Aug 10, 2004·The Journal of Experimental Biology·Philip E Bickler
Nov 17, 2004·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Leslie Thomas Buck
Feb 8, 2005·The Journal of Experimental Biology·Michael S HedrickPhilip E Bickler
Dec 13, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Rochelle Buffenstein
Jan 6, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Austin P RossKelly L Drew
Apr 20, 2006·Respiratory Physiology & Neurobiology·L T Buck, M E Pamenter
May 23, 2006·Nature Reviews. Neuroscience·Jeffrey M Gidday
Nov 14, 2006·Journal of Chemical Neuroanatomy·Huiwen W ZhaoKelly L Drew
Feb 17, 2009·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Pamela Colleen LaVinkaThomas J Park
Oct 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Andrei SeluanovVera Gorbunova
Nov 13, 2009·Neuroreport·John Larson, Thomas J Park
Oct 5, 2010·Experimental Gerontology·Yael H EdreyRochelle Buffenstein
Dec 1, 2010·Proceedings of the National Academy of Sciences of the United States of America·Aaron AviviThomas Hankeln
Feb 1, 1994·Trends in Ecology & Evolution·J U JarvisP W Sherman
Mar 5, 2011·The Journal of Biological Chemistry·Marina V KasaikinaVadim N Gladyshev

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Citations

Oct 3, 2012·PloS One·Pamela Colleen LaVinka, Thomas J Park
Jan 27, 2016·Ecology and Evolution·John R SpeakmanColin Selman
Sep 30, 2015·Behavioural Brain Research·Silvia Honda TakadaMaria Inês Nogueira
Jun 7, 2014·Frontiers in Neuroanatomy·Irmgard AmreinMaria K Oosthuizen
Nov 28, 2019·Biology Letters·Chris G FaulkesDunja Aksentijevic
Dec 25, 2019·Biochemistry. Biokhimii︠a︡·N A Popov, V P Skulachev
Feb 17, 2017·Physiological Reviews·Vladimir P SkulachevViktor A Sadovnichii
Dec 7, 2018·PloS One·Matthew E PamenterJeffrey G Richards
Feb 7, 2020·Physiology·Rochelle BuffensteinHolly M Brown-Borg
May 11, 2019·BMC Genomics·María Torres-SánchezDiego San Mauro
Oct 27, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Brigitte M BroweThomas J Park
Nov 1, 2020·Biological Reviews of the Cambridge Philosophical Society·Stan BraudeThomas B Hildebrandt
Aug 18, 2020·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Tina H WangMatthew E Pamenter
Mar 29, 2014·The Journal of Experimental Biology·John LarsonThomas J Park
Sep 3, 2021·The Journal of Physiology·Hang Cheng, Matthew E Pamenter

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