Blunted pressure natriuresis in ovariectomized Dahl-Iwai salt-sensitive rats

Hypertension
K OtsukaT Saruta

Abstract

Our objective was to determine whether increased salt sensitivity after menopause precedes the development of overt hypertension. We investigated the effect of ovariectomy on pressure natriuresis in Dahl-Iwai salt-sensitive (DS) and salt-resistant (DR) rats by in vivo perfusion studies. Differences in the neural and hormonal backgrounds of the kidney were minimized by renal denervation and by holding plasma vasopressin, aldosterone, corticosterone, and norepinephrine levels constant by intravenous infusion. The pressure-natriuresis relationship was blunted in DS rats compared with DR rats (slope, 0.30 versus 0.63 mumol.min-1.g kidney wt-1.mm Hg-1, P < .01). The impaired pressure-natriuresis response of DS rats was further blunted by ovariectomy (from 0.30 to 0.14 mumol.min-1.g kidney wt-1.mm Hg-1, P < .05), and that of DR rats was not. The ovariectomized DS rats developed hypertension earlier than sham-operated DS rats by salt loading. These results show that ovariectomy enhances genetic salt sensitivity by blunting the pressure-natriuresis relationship, which precedes the development of overt hypertension in female DS rats.

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Citations

Sep 9, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hiromichi Suzuki, Kazuoki Kondo
Aug 22, 2000·Acta Physiologica Scandinavica·R G EvansW P Anderson
Sep 13, 2003·Kidney International·Antoinette Pechère-BertschiMichel Burnier
Apr 29, 2006·American Journal of Nephrology·Ivonne Hernandez Schulman, Leopoldo Raij
Dec 22, 2007·American Journal of Nephrology·Rie Hoshi-FukushimaHiromichi Suzuki
May 5, 2017·American Journal of Physiology. Renal Physiology·Eman Y GoharDavid M Pollock
Jan 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Baojian XueMeredith Hay
Apr 24, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Hong JiKathryn Sandberg
Sep 24, 2019·American Journal of Physiology. Renal Physiology·John P Rapp, Michael R Garrett
Dec 9, 1998·The American Journal of Physiology·L C SharkeyM J Radin

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