Abstract
To investigate the response of erythropoietin (EPO) to anemia in patients polytransfused for beta-thalassemia major. We measured the serum EPO levels and the concurrent hemoglobin (Hb) concentrations in 40 patients polytransfused for beta-thalassemia major, in 18 patients with iron deficiency anemia (IDA), and 32 healthy subjects. Serum EPO levels were assayed by an enzyme immunoassay. In both groups with beta-thalassemia major and IDA, serum EPO levels were significantly elevated (114 +/- 71 and 239 +/- 217 mU/mL, respectively). There was a significant inverse correlation between log EPO values and Hb concentrations in patients with beta-thalassemia major (r = 0.61; p < 0.01) and IDA (r = 0.81; p < 0.01). In a semilogarithmic plot, the slope of the regression line obtained in patients with beta-thalassemia major was significantly lower than that of IDA (p < 0.01), suggesting a blunted EPO response to anemia in patients polytransfused for beta-thalassemia major. The elevation of serum EPO in patients with beta-thalassemia major was poorly related to clinical variables except serum ferritin. We conclude that a significant inverse relationship between serum EPO levels and Hb concentration exists in patients with beta-thalassemia ...Continue Reading
References
Nov 1, 1992·International Journal of Cell Cloning·A UrabeF Takaku
Nov 1, 1992·International Journal of Cell Cloning·J S ChenC J Tsao
Jan 1, 1992·Hemoglobin·B P AlterR S Weinberg
Apr 1, 1992·The Journal of Pediatrics·G L BrayR O'Donnell
Oct 1, 1991·European Journal of Haematology·S IannelliA Balestrieri
May 9, 1991·The New England Journal of Medicine·A J Erslev
Jan 1, 1990·European Journal of Haematology·D T BowenT C Lewis
Jun 14, 1990·The New England Journal of Medicine·C B MillerJ L Spivak
Apr 1, 1990·European Journal of Pediatrics·K U EckardtA Kurtz
Dec 9, 1988·Science·M A GoldbergH F Bunn
Dec 1, 1988·The Journal of Pediatrics·M ChandraM I McVicar
Aug 1, 1987·British Journal of Haematology·A N BaerS B Krantz
Sep 1, 1986·Scandinavian Journal of Haematology·D ManorE A Rachmilewitz
Feb 1, 1986·Journal of Cellular Physiology·H KimuraJ W Adamson
Oct 1, 1983·The Journal of Pediatrics·M S BrownP R Dallman
Nov 1, 1984·The Journal of Pediatrics·M S BrownP R Dallman
Jan 1, 1982·Acta Haematologica·G RicciT Bezzi
Dec 11, 1982·British Medical Journal·A G MorganG R Serjeant
Oct 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M SicilianoL Rossi
Apr 1, 1995·The Journal of Pediatrics·B Krafte-JacobsS J Soldin
Oct 1, 1994·British Journal of Haematology·H SchrezenmeierB Kubanek
Apr 15, 1994·Annals of the New York Academy of Sciences·K U EckardtA Kurtz
Apr 15, 1994·Annals of the New York Academy of Sciences·C Bauer
Citations
Apr 23, 2013·TheScientificWorldJournal·Jean-Antoine RibeilOlivier Hermine
Apr 8, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nunziata MorabitoNicola Frisina
Jan 19, 2016·Current Opinion in Hematology·Jean-Benoît ArletGeneviève Courtois