Blunted vascular and renal effects of exogenous atrial natriuretic peptide in patients with cushing's disease

The Journal of Clinical Endocrinology and Metabolism
C SalaA Morganti

Abstract

The role of atrial natriuretic peptide (ANP) in glucocorticoid hypertension is still controversial, as glucocorticoids enhance the secretion of ANP in vivo, but reduce its biological activity in vitro. In isolated cells, for example, the cGMP response to ANP is suppressed by dexamethasone. We tested the in vivo relevance of this observation by comparing the cGMP, endocrine, and renal responses to exogenous ANP in patients with Cushing's disease (CD; n = 10) and in a matched group of essential hypertensives (EH; n = 8) and normotensive controls (N; n = 4). alpha-human-ANP was infused at 0.01 microg/kg/min for 120 min with a 30-min recovery period; hormonal and arterial pressure measurements were performed at 30-min intervals, and renal parameters were measured at baseline and after infusion. There was a 4-fold increase in plasma ANP in all groups, but the increments in plasma cGMP were about 50% lower in CD than in N and EH; urinary cGMP was similarly lower in CD (247 +/- 61 vs. 529 +/- 146 and 384 +/- 54 nmol/150 min, respectively). This was associated with a reduced peak increase in hematocrit in CD (+2.6 +/- 0.9%) compared with N (+6.6 +/- 0.9%) and EH (+7.1 +/- 0.7%; P < 0.05 CD vs. both); the diuretic and natriuretic effect...Continue Reading

Citations

Aug 21, 2008·The Journal of Biological Chemistry·Michael HartmannMichaela Kuhn
Nov 6, 2004·Current Hypertension Reports·Smita Baid, Lynnette K Nieman
May 14, 2011·Endocrinology and Metabolism Clinics of North America·Susmeeta T Sharma, Lynnette K Nieman
Jul 27, 2010·General and Comparative Endocrinology·Pascale SmetsSylvie Daminet
Oct 24, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Laura M NallyGail Wright

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