Blunting of exercise-induced tachycardia and renin release 24 hours after a single dose of sotalol

Journal of Clinical Pharmacology
W KiowskiM Küng

Abstract

Sotalol significantly reduces resting and exercise-stimulated heart rate and plasma renin activity 2 hours and to a lesser degree also 24 hours after oral administration of a single 200-mg dose in healthy volunteers. Because of this 24-hour beta-adrenoceptor blocking effect, sotalol should be suitable for once-daily dosing in clinical practice.

References

Jun 1, 1975·Clinical Science and Molecular Medicine. Supplement·F R BühlerF Burkart
Jul 1, 1976·Acta Pharmacologica Et Toxicologica·M AnttilaH Sundquist
Jan 1, 1976·Current Medical Research and Opinion·R Gabriel
Aug 1, 1976·Australian and New Zealand Journal of Medicine·F R BühlerF J Koller
Apr 1, 1972·Kidney International·J E SealeyJ H Laragh
Aug 2, 1973·The New England Journal of Medicine·B Blackwell

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Citations

Jan 1, 1981·European Journal of Clinical Pharmacology·A Jäättelä
Feb 1, 1993·Journal of Cardiovascular Electrophysiology·R Ruffy

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