BLyS-mediated modulation of naive B cell subsets impacts HIV Env-induced antibody responses.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Pia DosenovicG B Karlsson Hedestam

Abstract

Neutralizing Abs provide the protective effect of the majority of existing human vaccines. For a prophylactic vaccine against HIV-1, broadly neutralizing Abs targeting conserved epitopes of the viral envelope glycoproteins (Env) are likely required, because the pool of circulating HIV-1 variants is extremely diverse. The failure to efficiently induce broadly neutralizing Abs by vaccination may be due to the use of suboptimal immunogens or immunization regimens, or it may indicate that B cells specific for broadly neutralizing Env determinants are selected against during peripheral checkpoints, either before or after Ag encounter. To investigate whether perturbation of B cell subsets prior to immunization with recombinant Env protein affects the vaccine-induced Ab response in mice, we used B lymphocyte stimulator (BLyS), a cytokine that regulates survival and selection of peripheral B cells. We show that the transient BLyS treatment used in this study substantially affected naive B cell populations; in particular, it resulted in more B cells surviving counter-selection at the transitional stages. We also observed more mature naive B cells, especially marginal zone B cells, in BLyS-treated mice. Intriguingly, provision of excess ...Continue Reading

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Citations

Feb 8, 2013·Nature Medicine·Hendrik StreeckShane Crotty
Jan 5, 2013·Proceedings of the National Academy of Sciences of the United States of America·Lindsey M PujanauskiRaul M Torres
Jan 14, 2016·Cancer Immunology, Immunotherapy : CII·Anirudh SaraswathulaJohn H Sampson
Oct 15, 2014·Immunology and Cell Biology·Pia DosenovicGunilla B Karlsson Hedestam
Jan 31, 2017·Immunological Reviews·Gunilla B Karlsson HedestamRichard T Wyatt
Sep 10, 2014·Viruses·Martina SoldemoGunilla B Karlsson Hedestam
Dec 13, 2017·Frontiers in Immunology·Martina SoldemoGunilla B Karlsson Hedestam
Sep 27, 2019·Immunological Reviews·Deborah L BurnettChristopher C Goodnow
Jul 13, 2017·The Journal of Experimental Medicine·Kristin M S SchroederRaul M Torres
Apr 25, 2018·Viruses·Lyvia FourcadeMichel Roger

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